Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making.

Autor:	Grossman CD; The Solomon H. Snyder Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: jeremiah.cohen@jhmi.edu., Cohen JY; The Solomon H. Snyder Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: jeremiah.cohen@jhmi.edu.
Jazyk:	angličtina
Zdroj:	Annual review of neuroscience [Annu Rev Neurosci] 2022 Jul 08; Vol. 45, pp. 317-337. Date of Electronic Publication: 2022 Apr 01.
DOI:	10.1146/annurev-neuro-092021-125059
Abstrakt:	Nervous systems evolved to effectively navigate the dynamics of the environment to achieve their goals. One framework used to study this fundamental problem arose in the study of learning and decision-making. In this framework, the demands of effective behavior require slow dynamics-on the scale of seconds to minutes-of networks of neurons. Here, we review the phenomena and mechanisms involved. Using vignettes from a few species and areas of the nervous system, we view neuromodulators as key substrates for temporal scaling of neuronal dynamics.
Databáze:	MEDLINE
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