Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients.

Autor:	Topi G; Division of Cell Pathology, Skåne University Hospital, Lund University, Malmö, Sweden., Ghatak S; Division of Cell Pathology, Skåne University Hospital, Lund University, Malmö, Sweden., Satapathy SR; Division of Cell Pathology, Skåne University Hospital, Lund University, Malmö, Sweden., Ehrnström R; Division of Pathology, Department of Translational Medicine, Skåne University Hospital, Lund University, Malmö, Sweden., Lydrup ML; Division of Surgery, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden., Sjölander A; Division of Cell Pathology, Skåne University Hospital, Lund University, Malmö, Sweden.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Mar 14; Vol. 9, pp. 739620. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.739620
Abstrakt:	We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45, P <0.0001) and DFS (HR = 0.10; 95% CI: 0.03-0.26, P < 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Topi, Ghatak, Satapathy, Ehrnström, Lydrup and Sjölander.)
Databáze:	MEDLINE
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