Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure.

Autor:	Radhakrishnan R; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States., Vishnubhotla RV; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States., Zhao Y; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States., Yan J; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States., He B; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States., Steinhardt N; Indiana University School of Medicine, Indianapolis, IN, United States., Haas DM; Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States., Sokol GM; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States., Sadhasivam S; Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2022 Mar 14; Vol. 10, pp. 847037. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).
DOI:	10.3389/fped.2022.847037
Abstrakt:	Background: Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict behavioral outcomes in these children. In this study, using resting-state functional MRI in early infancy, we aim to identify differences in global brain network connectivity in infants with prenatal opioid and substance exposure compared to healthy control infants. Methods and Materials: In this prospective study, we recruited 23 infants with prenatal opioid exposure and 29 healthy opioid naïve infants. All subjects underwent brain resting-state functional MRI before 3 months postmenstrual age. Covariate Assisted Principal (CAP) regression was performed to identify brain networks within which functional connectivity was associated with opioid exposure after adjusting for sex and gestational age. Associations of these significant networks with maternal comorbidities were also evaluated. Additionally, graph network metrics were assessed in these CAP networks. Results: There were four CAP network components that were significantly different between the opioid exposed and healthy control infants. Two of these four networks were associated with maternal psychological factors. Intra-network graph metrics, namely average flow coefficient, clustering coefficient and transitivity were also significantly different in opioid exposed infants compared to healthy controls. Conclusion: Prenatal opioid exposure is associated with alterations in global brain functional networks compared to non-opioid exposed infants, with intra-network alterations in graph network modeling. These network alterations were also associated with maternal comorbidity, especially mental health. Large-scale longitudinal studies can help in understanding the clinical implications of these early brain functional network alterations in infants with prenatal opioid exposure. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Radhakrishnan, Vishnubhotla, Zhao, Yan, He, Steinhardt, Haas, Sokol and Sadhasivam.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu