Thermoresponsive Glycopolypeptide Containing Block Copolymers, Particle Formation, and Lectin Interaction.
Autor: | Mokrus M; Institute for Technical Chemistry, Technische Universität Braunschweig, Hagenring 30, Braunschweig, 38106, Germany., Menzel H; Institute for Technical Chemistry, Technische Universität Braunschweig, Hagenring 30, Braunschweig, 38106, Germany. |
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Jazyk: | angličtina |
Zdroj: | Macromolecular bioscience [Macromol Biosci] 2022 Jun; Vol. 22 (6), pp. e2100518. Date of Electronic Publication: 2022 Apr 11. |
DOI: | 10.1002/mabi.202100518 |
Abstrakt: | Amphiphilic block copolymers with a thermoresponsive poly(N-isopropylacrylamide) block and a glycopeptide block are synthesized and particle formation as well as interaction of the glyco-corona with lectins is investigated. The synthetic route comprises the preparation of block copolymers by N-carboxyanhydride polymerization and subsequent deprotection to obtain pH- and thermoresponsive poly(l-glutamic acid)-b-poly(N-isopropylacrylamide) (pGA-b-pNIPAM), which is then further modified with different amino sugars by a versatile coupling method with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride (DMT-MM). The glycosylated pGA-b-pNIPAM block copolymers are investigated with regard to cloud point temperatures (T (© 2022 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.) |
Databáze: | MEDLINE |
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