Predictors of post-COVID symptoms in Egyptian patients: Drugs used in COVID-19 treatment are incriminated.

Autor: Abdelhafiz AS; Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt., Ali A; Department of Pulmonary Medicine, Abbassia Chest Hospital, MOH, Cairo, Egypt.; Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Maaly AM; Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt., Mahgoub MA; Department of Community Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Ziady HH; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China., Sultan EA; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Mar 31; Vol. 17 (3), pp. e0266175. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0266175
Abstrakt: Objectives: COVID-19 is a multisystem disease, and some patients suffer from physical or psychological symptoms for weeks or even months after infection, which is described as post-COVID syndrome. The goal of this study is evaluating the prevalence of post-COVID-19 symptoms among Egyptian patients and detecting the factors associated with the presence of these symptoms.
Methods: An on-line cross-sectional survey using Google Forms was used to conduct the present study, which took place between June and August 2021.
Results: Three hundred and ninety-six participants filled in the survey. The mean age of participants was 41.4 years. Most participants had mild to moderate COVID-19 (81.31%). The prevalence of post-COVID-19 symptoms was 87.63%, where the most frequent symptom was fatigue (60.86%). Female sex, the presence of comorbidities, lower degree of education, longer disease duration, as well as severe and critical forms of the disease were significantly associated with the presence of post-COVID symptoms. Using regression analysis, the predictors of post-COVID symptoms were severe and critical forms of the disease and intake of antibiotics and corticosteroids for treatment of COVID-19.
Conclusions: COVID-19 is followed by high prevalence of post-COVID symptoms. To the best of our knowledge, this is the first study to report the relationship between the use of antibiotics and the development of post-COVID symptoms. We recommend further studies to understand this relationship. We also recommend restricting the use of these drugs to indicated cases according to the international guidelines. More studies are needed to gain better understanding of post-COVID symptoms especially in females.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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