Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol.

Autor: Cortez B; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Valdivia C; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Keating D; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Marengi D; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Bates T; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Brown C; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Dairi I; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Doyle M; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Keske R; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America., Connor A; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Neurology, Berenson Allen Center and Division for Cognitive Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America., Grashow R; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, Massachusetts, United States of America., Tenforde A; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts, United States of America., Wasfy MM; Department of Internal Medicine, Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Weisskopf MG; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, Massachusetts, United States of America., Speizer F; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Zafonte R; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts, United States of America., Baggish A; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Internal Medicine, Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Mar 31; Vol. 17 (3), pp. e0265737. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0265737
Abstrakt: Background: Participation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate sample size, or focus on a single disease process in isolation.
Objective: To determine the burden of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.
Methods: The In-Person Assessment is a case-control, multi-day, deep human phenotyping protocol designed to characterize and quantify pathology among former professional ASF players. Participants, recruited from an on-going large-scale longitudinal cohort study, will include 120 men who report either no health conditions, a single health condition, or multiple health conditions across the key domains of cardiometabolic disease, disordered sleep, chronic pain, and cognitive impairment. Data will be collected from validated questionnaires, structured interviews, physical examinations, multi-modality imaging, and functional assessments over a 3-day study period. A pilot study was conducted to assess feasibility and to obtain participant feedback which was used to shape the final protocol.
Results: This study provides a comprehensive assessment of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.
Conclusion: The study will determine whether subjective health complaints among former professional ASF players are explained by objective explanatory pathology and will provide novel opportunities to examine the interrelatedness of co-morbidities. It is anticipated that this protocol will be applicable to other clinical and occupational populations.
Competing Interests: The authors declare that no competing interests exist.
Databáze: MEDLINE
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