The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study.

Autor:	Ahirwar AK; Department of Biochemistry, University College of Medical Sciences, New Delhi, 110095, India., Takhelmayum R; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, 441108, India., Sakarde A; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, 441108, India., Rathod BD; Department of Medicine, All India Institute of Medical Sciences, Nagpur, Maharashtra, 441108, India., Jha PK; Department of Biochemistry, University College of Medical Sciences, New Delhi, 110095, India., Kumawat R; Department of Biochemistry, All India Institute of Medical Sciences, Bathinda, Punjab, 151001, India., Gopal N; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, 441108, India.
Jazyk:	angličtina
Zdroj:	Hormone molecular biology and clinical investigation [Horm Mol Biol Clin Investig] 2022 Mar 31; Vol. 43 (3), pp. 337-344. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
DOI:	10.1515/hmbci-2021-0088
Abstrakt:	Objectives: The cut off values for serum high sensitivity C-reactive protein (hsCRP), ferritin, interleukin 6 (IL-6) and plasma D-dimer could be of profound help in detecting COVID-19 patients at risk of adverse outcomes. Therefore, the aim of the present study is to determine the cut off values of the serum hsCRP, ferritin, IL-6 and plasma D-dimer in predicting mortality in COVID-19 patients. Methods: Four hundred RT-PCR confirmed cases of COVID-19 were sub divided into two groups based on their outcome during hospitalisation. Group I consisted of survivors and Group II consisted of non-survivors. The survivors were further divided into three sub-groups: mild, moderate and severe based on the severity of infection. The laboratory data of serum hsCRP, ferritin, IL-6 and plasma D-dimer for all these patients was retrieved from the Medical Record Section of the Hospital. Results: Mean serum hsCRP, ferritin, IL-6 and plasma D-dimer levels were significantly higher in non-survivors as compared to survivors of COVID-19. The levels of these biomarkers correlated with the severity of COVID-19 illness. ROC curve analysis revealed that plasma D-dimer is having a better predictive value as compared to other parameters in predicting mortality in COVID-19. Conclusions: The serum hsCRP, ferritin, IL-6 and plasma D-dimer levels could be used in risk stratification of COVID-19 patients. The optimum cut off given by the current study could be considered in predicting adverse outcome in these patients. Amongst the many studied biomarkers, plasma D-dimer might be the best early biomarker to predict mortality in COVID-19 patients. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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