A risk score for predicting death in COVID-19 in-hospital infection: A Brazilian single-center study.

Autor: Vieira MLC; Hospital Israelita Albert Einstein, São Paulo, Brazil., Afonso TR; Hospital Israelita Albert Einstein, São Paulo, Brazil., Oliveira AJ; Hospital Israelita Albert Einstein, São Paulo, Brazil., Stangenhaus C; Hospital Israelita Albert Einstein, São Paulo, Brazil., Dantas JCD; Hospital Israelita Albert Einstein, São Paulo, Brazil., Santos LOA; Hospital Israelita Albert Einstein, São Paulo, Brazil., de França LA; Hospital Israelita Albert Einstein, São Paulo, Brazil., do Prado RR; Hospital Israelita Albert Einstein, São Paulo, Brazil., Cordovil A; Hospital Israelita Albert Einstein, São Paulo, Brazil., Monaco CG; Hospital Israelita Albert Einstein, São Paulo, Brazil., Lira Filho EB; Hospital Israelita Albert Einstein, São Paulo, Brazil., Rodrigues ACT; Hospital Israelita Albert Einstein, São Paulo, Brazil., Bacal F; Hospital Israelita Albert Einstein, São Paulo, Brazil., de Matos GFJ; Hospital Israelita Albert Einstein, São Paulo, Brazil., Antunes T; Hospital Israelita Albert Einstein, São Paulo, Brazil., Camargo LFA; Hospital Israelita Albert Einstein, São Paulo, Brazil., Fischer CH; Hospital Israelita Albert Einstein, São Paulo, Brazil., Morhy SS; Hospital Israelita Albert Einstein, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of clinical ultrasound : JCU [J Clin Ultrasound] 2022 Jun; Vol. 50 (5), pp. 604-610. Date of Electronic Publication: 2022 Mar 30.
DOI: 10.1002/jcu.23195
Abstrakt: Background: There is a paucity of information about Brazilian COVID-19 in-hospital mortality probability of death combining risk factors.
Objective: We aimed to correlate COVID-19 Brazilian in-hospital patients' mortality to demographic aspects, biomarkers, tomographic, echocardiographic findings, and clinical events.
Methods: A prospective study, single tertiary center in Brazil, consecutive patients hospitalized with COVID-19. We analyzed the data from 111 patients from March to August 2020, performed a complete transthoracic echocardiogram, chest thoracic tomographic (CT) studies, collected biomarkers and correlated to in-hospital mortality.
Results: Mean age of the patients: 67 ± 17 years old, 65 (58.5%) men, 29 (26%) presented with systemic arterial hypertension, 18 (16%) with diabetes, 11 (9.9%) with chronic obstructive pulmonary disease. There was need for intubation and mechanical ventilation of 48 (43%) patients, death occurred in 21/111 (18.9%) patients. Multiple logistic regression models correlated variables with mortality: age (OR: 1.07; 95% CI 1.02-1.12; p: 0.012; age >74 YO AUC ROC curve: 0.725), intubation need (OR: 23.35; 95% CI 4.39-124.36; p < 0.001), D dimer (OR: 1.39; 95% CI 1.02-1.89; p: 0.036; value >1928.5 ug/L AUC ROC curve: 0.731), C-reactive protein (OR: 1.18; 95% CI 1.05-1.32; p < 0.005; value >29.35 mg/dl AUC ROC curve: 0.836). A risk score was created to predict intrahospital probability of death, by the equation: 3.6 (age >75 YO) + 66 (intubation need) + 28 (C-reactive protein >29) + 2.2 (D dimer >1900).
Conclusions: A novel and original risk score were developed to predict the probability of death in Covid 19 in-hospital patients concerning combined risk factors.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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