Neural readout of a latency code in the active electrosensory system.

Autor:	Perks KE; Department of Biology, Wesleyan University, Middletown, CT 06459, USA; Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY 10027, USA., Sawtell NB; Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY 10027, USA. Electronic address: ns2635@columbia.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2022 Mar 29; Vol. 38 (13), pp. 110605.
DOI:	10.1016/j.celrep.2022.110605
Abstrakt:	The latency of spikes relative to a stimulus conveys sensory information across modalities. However, in most cases, it remains unclear whether and how such latency codes are utilized by postsynaptic neurons. In the active electrosensory system of mormyrid fish, a latency code for stimulus amplitude in electroreceptor afferent nerve fibers (EAs) is hypothesized to be read out by a central reference provided by motor corollary discharge (CD). Here, we demonstrate that CD enhances sensory responses in postsynaptic granular cells of the electrosensory lobe but is not required for reading out EA input. Instead, diverse latency and spike count tuning across the EA population give rise to graded information about stimulus amplitude that can be read out by standard integration of converging excitatory synaptic inputs. Inhibitory control over the temporal window of integration renders two granular cell subclasses differentially sensitive to information derived from relative spike latency versus spike count. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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