Development of Noninvasive Technology of Stereotaxic Radioablation Using Linear Accelerators for the Treatment of Life-Threatening Ventricular Tachycardias in Experiment.

Autor: Vaskovskii VA; A. V. Vishnevsky National Medical Research Center of Surgery, Ministry of the Health of the Russian Federation, Moscow, Russia. vvaskov03@mail.ru., Taimasova IA; A. V. Vishnevsky National Medical Research Center of Surgery, Ministry of the Health of the Russian Federation, Moscow, Russia., Artyukhina EA; A. V. Vishnevsky National Medical Research Center of Surgery, Ministry of the Health of the Russian Federation, Moscow, Russia., Golanov AV; N. N. Burdenko National Medical Research Center of Neurosurgery, Ministry of the Health of the Russian Federation, Moscow, Russia., Revishvili AS; A. V. Vishnevsky National Medical Research Center of Surgery, Ministry of the Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Mar; Vol. 172 (5), pp. 612-616. Date of Electronic Publication: 2022 Mar 30.
DOI: 10.1007/s10517-022-05445-y
Abstrakt: We developed a new technique of noninvasive stereotactic radioablation for the treatment of life-threatening tachyrhythmias. The study is performed on pigs (Sus scrofa domesticus). The zones of planned exposure were atrioventricular node (heart loading dose 40 Gy) and the apex of the left ventricle with a part of the interventricular septum (35 Gy) in animal No. 1 and atrioventricular node (45 Gy) and free wall of the left ventricle (40 Gy) in animal No. 2. The study was conducted on the Varian TrueBeam linear accelerator. The planned follow-up duration was 6 months. Delivery of 40 Gy to the atrioventricular node did not lead to persistent electrophysiological effect due to the development of transient third-degree atrioventricular block. The dose of 45 Gy resulted in permanent third-degree atrioventricular block followed by development of ventricular standstill on day 21 of observation. Histological examination confirmed transmurality and high precision of performed intervention.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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