Functional brain networks assessed with surface electroencephalography for predicting motor recovery in a neural guided intervention for chronic stroke.

Autor:	Sun R; The Laboratory of Neuroscience for Education, Faculty of Education, the University of Hong Kong, Pokfulam, Hong Kong, China., Wong WW; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Wang J; School of Mechanical Engineering, Xi'an Jiaotong University, Shaanxi, China., Wang X; Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China., Tong RKY; Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2021 Sep 25; Vol. 3 (4), pp. fcab214. Date of Electronic Publication: 2021 Sep 25 (Print Publication: 2021).
DOI:	10.1093/braincomms/fcab214
Abstrakt:	Predicting whether a chronic stroke patient is likely to benefit from a specific intervention can help patients establish reasonable expectations. It also provides the basis for candidates selecting for the intervention. Recent convergent evidence supports the value of network-based approach for understanding the relationship between dysfunctional neural activity and motor deficits after stroke. In this study, we applied resting-state brain connectivity networks to investigate intervention-specific predictive biomarkers of motor improvement in 22 chronic stroke participants who received either combined action observation with EEG-guided robot-hand training (Neural Guided-Action Observation Group, n  = 12, age: 34-68 years) or robot-hand training without action observation and EEG guidance (non-Neural Guided-text group, n  = 10, age: 42-57 years). The robot hand in Neural Guided-Action Observation training was activated only when significant mu suppression (8-12 Hz) was detected from participant's EEG signals in ipsilesional hemisphere while it was randomly activated in non-Neural Guided-text training. Only the Neural Guided-Action Observation group showed a significant long-term improvement in their upper-limb motor functions ( P  < 0.5). In contrast, no significant training effect on the paretic motor functions was found in the non-Neural Guided-text group ( P  > 0.5). The results of brain connectivity estimated via EEG coherence showed that the pre-training interhemispheric connectivity of delta, theta, alpha and contralesional connectivity of beta were motor improvement related in the Neural Guided-Action Observation group. They can not only differentiate participants with good and poor recovery (interhemispheric delta: P  = 0.047, Hedges' g  = 1.409; interhemispheric theta: P  = 0.046, Hedges' g  = 1.333; interhemispheric alpha: P  = 0.038, Hedges' g  = 1.536; contralesional beta: P  = 0.027, Hedges' g  = 1.613) but also significantly correlated with post-training intervention gains (interhemispheric delta: r = -0.901, P  < 0.05; interhemispheric theta: r = -0.702, P  < 0.05; interhemispheric alpha: r = -0.641, P  < 0.05; contralesional beta: r = -0.729, P  < 0.05). In contrast, no EEG coherence was significantly correlated with intervention gains in the non-Neural Guided-text group (all P s > 0.05 ). Partial least square regression showed that the combination of pre-training interhemispheric and contralesional local connectivity could precisely predict intervention gains in the Neural Guided-Action Observation group with a strong correlation between predicted and observed intervention gains ( r = 0.82 r = 0.82 ) and between predicted and observed intervention outcomes ( r = 0.90 r = 0.90 ). In summary, EEG-based resting-state brain connectivity networks may serve clinical decision-making by offering an approach to predicting Neural Guided-Action Observation training-induced motor improvement. (© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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