Echocardiographic Parameters to Predict Atrial Fibrillation in Clinical Routine-The EAHsy-AF Risk Score.

Autor: Sieweke JT; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Hagemus J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Biber S; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Berliner D; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Grosse GM; Department of Neurology, Hannover Medical School, Hannover, Germany., Schallhorn S; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Pfeffer TJ; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Derda AA; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Neuser J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Bavendiek U; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Jazyk: angličtina
Zdroj: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Mar 08; Vol. 9, pp. 851474. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022).
DOI: 10.3389/fcvm.2022.851474
Abstrakt: Background: Echocardiographic parameters representing impaired left atrial (LA) function and remodeling are of high value to predict atrial fibrillation (AF). This study aimed to develop a prediction model for AF easily to apply in clinical routine containing echocardiographic parameters associated with LA remodeling and-function.
Methods and Results: This monocentric, semi-blinded, controlled analysis included 235 patients to derive a prediction model. This prediction model was tested in a validation cohort encompassing 290 cardiovascular inpatients. The derivation and validation cohort included 54 (23%) and 66 (23%) patients with AF, respectively. Transthoracic echocardiography, comprising parameters indicating left atrial remodeling [septal/lateral total atrial conduction time (s/l PA-TDI)] and left atrial volume indexed to a' (LAVI/a') was performed in each patient. Based on multivariable regressions analysis, four variables were enclosed into the EAHsy (Echocardiography, Age, Hypertension)-AF risk score for AF prediction: Hypertension, Age, LAVI/a' and septal PA-TDI. In the validation cohort discrimination was strong (C-statistic 0.987, 95%CI 0.974-0.991) with an adequately performed calibration. The EAHsy-AF risk score was associated with a more precise prediction of AF in comparison to commonly used AF-scores (CHADS 2 -, ATLAS-, ARIC-, CHARGE-AF score).
Conclusion: The EAHsy-AF-Score containing age, hypertension and echocardiographic parameters of atrial dysfunction and remodeling precisely predicts the incidence of AF in a general population of patients with cardiovascular disease. The EAHsy-AF risk score may enable more selective rhythm monitoring in specific patients at high risk for AF.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Sieweke, Hagemus, Biber, Berliner, Grosse, Schallhorn, Pfeffer, Derda, Neuser, Bauersachs and Bavendiek.)
Databáze: MEDLINE
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