Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats.

Autor: Özkoç M; Department of Medical Biochemistry, Faculty of Medicine, Eastern Mediterranean University, Famagusta, Cyprus. ozkocmete@gmail.com., Can B; Department of Medical Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey., Şentürk H; Department of Biology, Faculty of Science and Letters, Eskisehir Osmangazi University, Eskişehir, Turkey., Burukoğlu Dönmez D; Department of Histology and Embryology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey., Kanbak G; Department of Medical Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2023 Mar; Vol. 201 (3), pp. 1237-1251. Date of Electronic Publication: 2022 Mar 29.
DOI: 10.1007/s12011-022-03215-5
Abstrakt: Crohn's disease (CD) and ulcerative colitis (UC) are two chronic relapsing inflammatory bowel diseases (IBD). Although there are several treatment options available to improve the symptoms of IBD patients, there is no effective treatment that provides a definitive solution. In the present study, we aim to investigate the antioxidative/anti-inflammatory effects of oral administration of boric acid and Bacillus clausii in a rat trinitrobenzenesulfonic acid (TNBS)-induced colitis model. The effects of boric acid and B. clausii were examined in serum and colon tissues with the help of some biochemical and histological analyses. Elevated inflammation and oxidative damage were found in the blood and colon tissue samples in the TNBS-induced group according to the complete blood count (CBC), tumor necrosis factor (TNF) alpha, interleukin-35 (IL-35), malondialdehyde (MDA), glutathione peroxidase (GPx), myeloperoxidase (MPO), nitric oxide (NO), and histological findings. Particularly, the highest IL-35 level (70.09 ± 12.62 ng/mL) in the combined treatment group, highest catalase activity (5322 ± 668.1 U/mg protein) in the TNBS-induced group, and lower relative expression of inducible nitric oxide synthase in the TNBS-induced group than the control group were striking findings. According to our results, it can be concluded that boric acid showed more curative effects, even if B. clausii probiotics was partially ameliorative.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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