| Autor: |
Lopera TJ; Grupo Inmunovirología, Universidad de Antioquia, Medellín, Antioquia, Colombia., Alzate-Ángel JC; Grupo Inmunovirología, Universidad de Antioquia, Medellín, Antioquia, Colombia., Díaz FJ; Grupo Inmunovirología, Universidad de Antioquia, Medellín, Antioquia, Colombia., Rugeles MT; Grupo Inmunovirología, Universidad de Antioquia, Medellín, Antioquia, Colombia., Aguilar-Jiménez W; Grupo Inmunovirología, Universidad de Antioquia, Medellín, Antioquia, Colombia. |
| Jazyk: |
angličtina |
| Zdroj: |
Microbiology spectrum [Microbiol Spectr] 2022 Apr 27; Vol. 10 (2), pp. e0196221. Date of Electronic Publication: 2022 Mar 29. |
| DOI: |
10.1128/spectrum.01962-21 |
| Abstrakt: |
Increasing the diagnostic capacity for COVID-19 (SARS-CoV-2 infection) is required to improve case detection, reduce COVID-19 expansion, and boost the world economy. Rapid antigen detection tests are less expensive and easier to implement, but their diagnostic performance has been questioned compared to reverse transcription-PCR (RT-PCR). Here, we evaluate the performance of the Standard Q COVID-19 antigen test for diagnosing SARS-CoV-2 infection and predicting contagiousness compared to RT-PCR and viral culture, respectively. The antigen test was 100.0% specific but only 40.9% sensitive for diagnosing infection compared to RT-PCR. Interestingly, SARS-CoV-2 contagiousness is highly unlikely with a negative antigen test since it exhibited a negative predictive value of 99.9% compared to viral culture. Furthermore, a cycle threshold ( C T ) value of 18.1 in RT-PCR was shown to be the one that best predicts contagiousness (area under the curve [AUC], 97.6%). Thus, screening people with antigen testing is a good approach to prevent SARS-CoV-2 contagion and allow returning to daily activities. IMPORTANCE The importance of our results is the excellent agreement between the Standard Q COVID-19 antigen test and the viral culture, indicating that it is important as a marker of contagiousness. Due to its high positive predictive value in situations of a high prevalence of infection, positive results do not require confirmation with another test. Likewise, its high negative predictive value for contagiousness makes possible to use this test as a criterion to discharge patients in isolation and screen people moving into environments that could facilitate the transmission of the virus. Screening people with antigen testing is a good approach to prevent SARS-CoV-2 contagion and allow returning to daily activities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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