Synthesis of a Bioactive Composition of Chitosan-Selenium Nanoparticles.

Autor: Apryatina KV; National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia., Murach EI; Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia., Amarantov SV; Federal Scientific Research Center 'Crystallography and Photonics' of RAS, Institute of Crystallography Named After A. Shubnikov RAS, 119333 Moscow, Russia., Erlykina EI; Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia., Veselov VS; National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia., Smirnova LA; National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
Jazyk: angličtina
Zdroj: Applied biochemistry and microbiology [Appl Biochem Microbiol] 2022; Vol. 58 (2), pp. 126-131. Date of Electronic Publication: 2022 Mar 24.
DOI: 10.1134/S0003683822020028
Abstrakt: A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2-3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs.
Competing Interests: Conflict of interests. The authors declare that they have no conflict of interest.
(© Pleiades Publishing, Inc. 2022, ISSN 0003-6838, Applied Biochemistry and Microbiology, 2022, Vol. 58, No. 2, pp. 126–131. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2022, Vol. 58, No. 2, pp. 140–145.)
Databáze: MEDLINE
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