HLA alleles and haplotype frequencies in Iranian population.

Autor: Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hussen BM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.; Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq.; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Pashmforoush S; Department of Biological Sciences, Kharazmi University, Karaj, Iran., Akbari MT; Tehran Medical Genetics Laboratory, Tehran, Iran., Arsang-Jang S; Department of Biostatistics and Epidemiology, Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran., Nazer N; Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran., Hamidieh AA; Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran., Hajifathali A; Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Dinger ME; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Sayad A; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Dehaghi MO; Cell Therapy and Hematopoietic Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Hematology, Oncology, and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Human antibodies [Hum Antibodies] 2022; Vol. 30 (2), pp. 79-96.
DOI: 10.3233/HAB-220004
Abstrakt: Background: HLA genotyping is a prerequisite for selection of suitable donors in the process of bone marrow transplantation.
Methods: In the current study, the frequencies of HLA-A, -B, -C and -DRB1 alleles and A-B-C-DRB1 haplotypes were assessed in 855 healthy Iranian persons using a low-resolution sequence specific primer (SSP) kit.
Results: Frequencies were compared between 11 subpopulations including Armani, Balouch, Bandari, Turk, Turkaman, Arab, Fars, Kurd, Gilaki, Lor and Mazani. In total, 17 HLA-A alleles were detected, one of which (HLA-A*74) was present only among Lors. HLA-A*23 and -A*26 were the most frequent HLA-A alleles among Armanis. HLA-A*23 was also common among Turkamans. HLA-A*11 and -A*26 were most frequent among the Balouch subpopulation. The former allele was also frequent among Bandaris. HLA-A*02 was identified as the most common HLA-A allele among Turk, Arab and Fars subpopulations. HLA-A*30 were strongly enriched among Gilakis. A total of 31 HLA-B alleles were detected across the target population. While all alleles were present among Fars subgroup, Armanis and Turkamans had the lowest degree of diversity among the alleles examined. Moreover, HLA-B*35 and B*49 alleles were strongly enriched among Armanis and Turkamans, respectively. A total of 13 HLA-C alleles were identified across the population, all of which were present in the Fars subpopulation. HLA-C*03 and C*04 were the only HLA-C alleles identified among the Bandari subpopulation. HLA-DRB1*08 was not detected in any subpopulation other than Fars. HLA-DRB1*16 was significantly enriched among Bandaris. These data have practical significance in anthropological studies, disease association investigations and bone marrow transplantation.
Databáze: MEDLINE
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