Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration.

Autor:	Anneveldt KJ; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.; Department of Gynecology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., van 't Oever HJ; Department of Emergency Healthcare, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., Verpalen IM; Department of Radiology, Amsterdam University Medical Center, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Nijholt IM; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., Bartels W; Image Sciences Institute, Imaging Division, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Dijkstra JR; Department of Gynecology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., van den Hoed RD; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., van 't Veer-Ten Kate M; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., de Boer E; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., Veersema S; Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Huirne JAF; Department of Obstetrics and Gynecology and Amsterdam research institute Reproduction and Development, Amsterdam University Medical Centre, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Schutte JM; Department of Gynecology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands., Boomsma MF; Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.
Jazyk:	angličtina
Zdroj:	European journal of radiology open [Eur J Radiol Open] 2022 Mar 21; Vol. 9, pp. 100413. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).
DOI:	10.1016/j.ejro.2022.100413
Abstrakt:	Purpose: We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids. Method: In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm 3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded. Results: Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration. Conclusion: Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
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