Cerebrovascular disease in suspected non-Alzheimer's pathophysiology and cognitive decline over time.

Autor: Saridin FN; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore., Chew KA; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore., Reilhac A; Clinical Imaging Research Centre, National University of Singapore, Singapore, Singapore., Gyanwali B; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Villaraza SG; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore., Tanaka T; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Scheltens P; Department of Neurology & Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., van der Flier WM; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands., Chen CLH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Department of Psychological Medicine, National University Hospital, Singapore, Singapore., Hilal S; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2022 Jul; Vol. 29 (7), pp. 1922-1929. Date of Electronic Publication: 2022 Apr 06.
DOI: 10.1111/ene.15337
Abstrakt: Background: The underlying cause of cognitive decline in individuals who are positive for biomarkers of neurodegeneration (N) but negative for biomarkers of amyloid-beta (A), designated as Suspected non-Alzheimer's pathophysiology (SNAP), remains unclear. We evaluate whether cerebrovascular disease (CeVD) is more prevalent in those with SNAP compared to A-N- and A+N+ individuals and whether CeVD is associated with cognitive decline over time in SNAP patients.
Methods: A total of 216 individuals from a prospective memory clinic cohort (mean [SD] age, 72.7 [7.3] years, 100 women [56.5%]) were included and were diagnosed as no cognitive impairment (NCI), cognitive impairment no dementia (CIND), Alzheimer's dementia (AD) or vascular dementia (VaD). All individuals underwent clinical evaluation and neuropsychological assessment annually for up to 5 years. Carbon 11-labeled Pittsburgh Compound B ([ 11 C]-PiB) or [ 18 F]-flutafuranol-positron emission spectrometry imaging was performed to ascertain amyloid-beta status. Magnetic resonance imaging was performed to assess neurodegeneration as measured by medial temporal atrophy ≥2, as well as significant CeVD (sCeVD) burden, defined by cortical infarct count ≥1, Fazekas score ≥2, lacune count ≥2 or cerebral microbleed count ≥2.
Results: Of the 216 individuals, 50 (23.1%) A-N+ were (SNAP), 93 (43.1%) A-N-, 36 (16.7%) A+N- and 37 (17.1%) A+N+. A+N+ individuals were significantly older, while A+N+ and SNAP individuals were more likely to have dementia. The SNAP group had a higher prevalence of sCeVD (90.0%) compared to A-N-. Moreover, SNAP individuals with sCeVD had significantly steeper decline in global cognition compared to A-N- over 5 years (p = 0.042).
Conclusions: These findings suggest that CeVD is a contributing factor to cognitive decline in SNAP. Therefore, SNAP individuals should be carefully assessed and treated for CeVD.
(© 2022 European Academy of Neurology.)
Databáze: MEDLINE
Externí odkaz: