COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review.

Autor:	Almamlouk R; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Kashour T; Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University Medical City, Riyadh, Saudi Arabia., Obeidat S; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Bois MC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Maleszewski JJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Omrani OA; The Royal London Hospital, Barts Health NHS Trust, London, UK; Barts and the London School of Medicine and Dentistry, Queen Mary University, London, UK., Tleyjeh R; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Berbari E; Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Chakhachiro Z; Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon., Zein-Sabatto B; Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon., Gerberi D; Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, USA., Tleyjeh IM; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Infectious Diseases Section, Department of Medical Specialties King Fahad Medical City, Riyadh, Saudi Arabia; Division of Epidemiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: Tleyjeh.Imad@mayo.edu., Paniz Mondolfi AE; Department of Pathology, Molecular and Cell-Based Medicine, New York, NY, USA., Finn AV; CVPath Institute, Inc., Gaithersburg, and University of Maryland, Baltimore, MD, USA., Duarte-Neto AN; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Rapkiewicz AV; NYU Winthrop Hospital, Department of Pathology, Long Island School of Medicine, Long Island, NY, USA., Frustaci A; Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, La Sapienza University, Rome, Italy; Cellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy., Keresztesi AA; Fogolyan Kristof Emergency County Hospital, Covasna County Institution of Forensic Medicine, Covasna, Romania., Hanley B; Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK; Centre for Inflammatory Disease, Imperial College London, London, UK., Märkl B; Institute of Pathology and Molecular Diagnostics, University Medical Center Augsburg, Augsburg, Germany., Lardi C; University Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland., Bryce C; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lindner D; Department of Cardiology, University Heart and Vascular Centre, Hamburg, Germany; DZHK-German Center for Cardiovascular Research, Partner site, Hamburg/Kiel/Lübeck, Germany., Aguiar D; University Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland., Westermann D; Department of Cardiology, University Heart and Vascular Centre, Hamburg, Germany; DZHK-German Center for Cardiovascular Research, Partner site, Hamburg/Kiel/Lübeck, Germany., Stroberg E; Office of the Chief Medical Examiner, Oklahoma City, OK, USA., Duval EJ; Office of the Chief Medical Examiner, Oklahoma City, OK, USA., Youd E; Forensic Medicine and Science, University of Glasgow, Glasgow, UK., Bulfamante GP; Unità di Anatomia Patologica, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy; Struttura Complessa di Anatomia Patologica e Genetica Medica, ASST Santi Paolo e Carlo, Milan, Italy., Salmon I; Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium; Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière, Jumet, Belgium; DIAPath, Center for Microscopy and Molecular Imaging, ULB, Gosselies, Belgium., Auer J; Department of Cardiology and Intensive Care, St. Josef Hospital Braunau, Austria; Department of Cardiology and Intensive Care, Kepler University of Medicine Linz, Austria., Maleszewski JJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Hirschbühl K; Department of Hematology and Clinical Oncology, University Medical Center Augsburg, Augsburg, Germany., Absil L; Department of Pathology, Erasme Hospital, ULB, Brussels, Belgium., Barton LM; Office of the Chief Medical Examiner, Oklahoma City, OK, USA., Ferraz da Silva LF; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Serviço de Verificação de Óbitos da Capital, Universidade de São Paulo, São Paulo, Brazil., Moore L; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Dolhnikoff M; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Lammens M; Department of Pathology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium., Bois MC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Osborn M; Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK; Death Investigation Committee, Royal College of Pathologists, London, UK; Nightingale NHS Hospital, London, UK., Remmelink M; Department of Pathology, Erasme Hospital, ULB, Brussels, Belgium., Nascimento Saldiva PH; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Jorens PG; Infla-Med Research Consortium of Excellence, University of Antwerp, Antwerp, Belgium; Department of Medicine and Health Sciences, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium; Department of Intensive Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium., Craver R; Children's Hospital of New Orleans and Louisiana State University Health Sciences Center, New Orleans, LA, USA., Aparecida de Almeida Monteiro R; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Scendoni R; Institute of Legal Medicine, Department of Law, University of Macerata, Macerata, Italy., Mukhopadhyay S; Department of Pathology, Cleveland Clinic, Cleveland, OH, USA., Suzuki T; National Institute of Infectious Diseases, Tokyo, Japan., Mauad T; Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Fracasso T; University Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland., Grimes Z; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2022 Aug; Vol. 28 (8), pp. 1066-1075. Date of Electronic Publication: 2022 Mar 23.
DOI:	10.1016/j.cmi.2022.03.021
Abstrakt:	Background: Many postmortem studies address the cardiovascular effects of COVID-19 and provide valuable information, but are limited by their small sample size. Objectives: The aim of this systematic review is to better understand the various aspects of the cardiovascular complications of COVID-19 by pooling data from a large number of autopsy studies. Data Sources: We searched the online databases Ovid EBM Reviews, Ovid Embase, Ovid Medline, Scopus, and Web of Science for concepts of autopsy or histopathology combined with COVID-19, published between database inception and February 2021. We also searched for unpublished manuscripts using the medRxiv services operated by Cold Spring Harbor Laboratory. Study Eligibility Criteria: Articles were considered eligible for inclusion if they reported human postmortem cardiovascular findings among individuals with a confirmed SARS coronavirus type 2 (CoV-2) infection. Participants: Confirmed COVID-19 patients with post-mortem cardiovascular findings. Interventions: None. Methods: Studies were individually assessed for risk of selection, detection, and reporting biases. The median prevalence of different autopsy findings with associated interquartile ranges (IQRs). Results: This review cohort contained 50 studies including 548 hearts. The median age of the deceased was 69 years. The most prevalent acute cardiovascular findings were myocardial necrosis (median: 100.0%; IQR, 20%-100%; number of studies = 9; number of patients = 64) and myocardial oedema (median: 55.5%; IQR, 19.5%-92.5%; number of studies = 4; number of patients = 46). The median reported prevalence of extensive, focal active, and multifocal myocarditis were all 0.0%. The most prevalent chronic changes were myocyte hypertrophy (median: 69.0%; IQR, 46.8%-92.1%) and fibrosis (median: 35.0%; IQR, 35.0%-90.5%). SARS-CoV-2 was detected in the myocardium with median prevalence of 60.8% (IQR 40.4-95.6%). Conclusions: Our systematic review confirmed the high prevalence of acute and chronic cardiac pathologies in COVID-19 and SARS-CoV-2 cardiac tropism, as well as the low prevalence of myocarditis in COVID-19. (Copyright © 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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