Glycan processing in gut microbiomes.

Autor: La Rosa SL; Faculty of Biosciences, Norwegian University of Life Sciences, Ås, 1433, Norway. Electronic address: sabina.leantilarosa@nmbu.no., Ostrowski MP; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, 48109, MI, USA., Vera-Ponce de León A; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, 1433, Norway., McKee LS; Division of Glycoscience, Department of Chemistry, KTH Royal Institute of Technology, AlbaNova University Centre, Stockholm, 106 91, Sweden., Larsbrink J; Division of Industrial Biotechnology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, 412 96, Sweden., Eijsink VG; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, 1433, Norway., Lowe EC; Biosciences Institute, Newcastle University, Newcastle, UK., Martens EC; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, 48109, MI, USA., Pope PB; Faculty of Biosciences, Norwegian University of Life Sciences, Ås, 1433, Norway; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, 1433, Norway.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2022 Jun; Vol. 67, pp. 102143. Date of Electronic Publication: 2022 Mar 23.
DOI: 10.1016/j.mib.2022.102143
Abstrakt: Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the utilization of common and atypical dietary glycans as well as host-derived mucus glycans. In parallel, we discuss findings from multi-omic studies that have provided new perspectives on understanding glycan-dependent interactions and the complex food-webs of microbial populations in their natural habitat. Using key examples, we emphasize how increasing understanding of glycan processing by gut microbiomes can provide critical insights to assist 'microbiome reprogramming', a growing field that seeks to leverage diet to improve animal growth and host health.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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