Epidemiological and Genetic Characterization of Norovirus Outbreaks That Occurred in Catalonia, Spain, 2017-2019.

Autor: Anfruns-Estrada E; Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain., Sabaté S; Laboratori de l'Agència de Salut Pública de Barcelona (ASPB), 08023 Barcelona, Spain., Razquin E; Laboratori de l'Agència de Salut Pública de Barcelona (ASPB), 08023 Barcelona, Spain., Cornejo Sánchez T; Microbiology Laboratory, Vall d'Hebron University Hospital, 08035 Barcelona, Spain., Bartolomé R; Microbiology Laboratory, Vall d'Hebron University Hospital, 08035 Barcelona, Spain., Torner N; Department of Health, Generalitat of Catalonia, 08005 Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain., Izquierdo C; Department of Health, Generalitat of Catalonia, 08005 Barcelona, Spain., Soldevila N; CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine, University of Barcelona, 08036 Barcelona, Spain., Coronas L; CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine, University of Barcelona, 08036 Barcelona, Spain., Domínguez À; CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine, University of Barcelona, 08036 Barcelona, Spain., Fuentes C; Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain., Pintó RM; Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain., Bosch A; Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain., Guix S; Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain., The Working Group For The Study Of Outbreaks Of Acute Gastroenteritis In Catalonia Pi/
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Feb 27; Vol. 14 (3). Date of Electronic Publication: 2022 Feb 27.
DOI: 10.3390/v14030488
Abstrakt: Molecular characterization of human norovirus (HuNoV) genotypes enhances the understanding of viral features and illustrates distinctive evolutionary patterns. The aim of our study was to describe the prevalence of the genetic diversity and the epidemiology of the genotypes involved in HuNoV outbreaks in Catalonia (Spain) between 2017 and 2019. A total of 100 HuNoV outbreaks were notified with the predominance of GII (70%), followed by GI (27%) and mixed GI/GII (3%). Seasonality was observed for GII outbreaks only. The most prevalent genotypes identified were GII.4[P31] Sydney 2012, GII.4[P16] Sydney 2012 and GII.2[P16]. As compared to person-to-person (P/P) transmitted outbreaks, foodborne outbreaks showed significantly higher attack rates and lower duration. The average attack rate was higher in youth hostel/campgrounds compared to nursing homes. Only genotypes GI.4[P4], GII.2[P16], GII.4[P16], GII.4[P31] and GII.17[P17] were consistently detected every year, and only abundance of GII.2[P16] showed a negative trend over time. GII.4 Sydney 2012 outbreaks were significantly associated to nursing homes, while GII.2[P16] and GI.3[P3] were most frequently identified in youth hostel/campgrounds. The average attack rate was significantly higher when comparing GII.2[P16] vs. GI.4[P4], GII.2[P16] vs. GII.4[P31] Sydney 2012, and GII.6[P7] vs. GII.4[P31] Sydney 2012. No correlations were found between genotype and outbreak duration or age of affected individuals.
Databáze: MEDLINE
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