| Autor: |
Figueiredo PS; Post-Graduate Program in Health and Development in the Mid-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Martins TN; Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Ravaglia LM; Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Alcantara GB; Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Guimarães RCA; Post-Graduate Program in Health and Development in the Mid-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Freitas KC; Post-Graduate Program in Health and Development in the Mid-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Nunes ÂA; Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande 79117-900, MS, Brazil., de Oliveira LCS; Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Cortês MR; Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Michels FS; Optics and Photonics Group, Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Kadri MCT; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Bonfá IS; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Filiú WFO; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Asato MA; Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., de Faria BB; Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Nascimento VAD; Post-Graduate Program in Health and Development in the Mid-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil., Hiane PA; Post-Graduate Program in Health and Development in the Mid-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil. |
| Abstrakt: |
Different fatty acid proportions produce potential inflammatory and metabolic changes in organisms. However, the evidence for how each fatty acid mediates the metabolic pathway, and its lipid stability remains controversial. To resolve this controversy, the present study investigated the metabolic effects of cold-pressed linseed (LG), coconut (CG), and baru (BG) oils in comparison to those of soybean oil (SG) in mice, in terms of their oil characterization and stability. The quality analysis showed less oxidative behavior among PUFA-rich oils (SO, BO, and LO, with induction periods lower than 2 h compared to 39.8 h for CG), besides the high contents of tocopherols and carotenoids in SG and LG. In the experimental study, CG presented higher triglyceride (257.93 ± 72.30) and VLDL-cholesterol levels (51.59 ± 14.46, p < 0.05), while LG reduced LDL levels (59.29 ± 7.56, p < 0.05) when compared to SG (183.14 ± 22.06, 36.63 ± 4.41 and 131.63 ± 29.0, respectively). For visceral fats, the adiposity index was lower for BG (7.32 ± 3.13) and CG (9.58 ± 1.02, p < 0.05) in relation to SG (12.53 ± 2.80), and for leukocyte recruitment, CG presented lower polymorphonuclear (PMN) (p < 0.0001) and mononuclear (MN) (p < 0.05) cell infiltration, demonstrating anti-inflammatory potential. In NMR-based metabolomics, although CG presented higher values for the glucose, lactate, and LDL/VLDL ratio, this group also evidenced high levels of choline, a lipotropic metabolite. Our study emphasized the controversies of saturated fatty acids, which impair serum lipids, while alfa-linolenic acid presented cardioprotective effects. However, coconut oil also has a positive immunomodulatory pathway and was found to reduce visceral bodyfat in mice. Therefore, for future applications, we suggest a combination of lauric and al-fa-linolenic acid sources, which are present in coconut and linseed oil, respectively. This combination could be less obesogenic and inflammatory and exert cardioprotective action. |
