Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France.

Autor: Rojas Rojas T; Aix-Marseille Univ, APHM Sainte-Marguerite, Clinical Immuno-Hematological Unit Marseille, Marseille, France., Poizot-Martin I; Aix-Marseille Univ, APHM Sainte-Marguerite, Clinical Immuno-Hematological Unit Marseille, Marseille, France.; Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, France., Rey D; Le Trait d'Union, HIV-Infection Care Center, Hôpitaux Universitaires de Strasbourg, Strasbourg, France., Duvivier C; APHP-Hôpital Necker-Enfants Malades, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, IHU Imagine, Paris, France.; Institut Cochin-CNRS 8104-INSERM U1016-RIL Team: Retrovirus, Infection and Latency, Université de Paris, Paris, France.; Centre Médical de l'Institut Pasteur, Institut Pasteur, Paris, France., Bani-Sadr F; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims, France., Cabie A; Université des Antilles, CHU de Martinique, Fort-de-France, Martinique, France., Delobel P; CHU de Toulouse, Service des Maladies Infectieuses et Tropicales-INSERM, UMR 1043- Université Toulouse III Paul Sabatier, Toulouse, France., Jacomet C; Clermont-Ferrand University Hospital Infectious and Tropical disease Department, Clermont Ferrand, France., Allavena C; Infectious Diseases Department, CHU Hôtel-Dieu, INSERM UIC 1413, CHU Nantes, Nantes, France., Ferry T; Service de Maladies Infectieuses, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France., Pugliese P; Université Côte d'Azur, CHU de Nice, Nice, France., Valantin MA; GHPS Pitié Salpêtrière APHP, Infectious Diseases, Paris, France.; Sorbonne Universités UPMC Université Paris 6-INSERM-IPLESP, Paris, France., Lamaury I; Department of Infectious and Tropical Diseases, University Hospital of Pointe-à-Pitre, Pointe-à-Pitre, France., Hustache-Matthieu L; Department of Infectious and Tropical Diseases, Jean Minjoz University Hospital, Besançon, France., Fresard A; Department of Infectious and Tropical Diseases, University Hospital of Saint-Etienne, Saint-Etienne, France., Houyou T; Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, France.; ORS PACA, Observatoire Régional De La Santé Provence-Alpes-Côte d'Azur, Marseille, France., Huleux T; Service Universitaire des Maladies Infectieuses et du Voyageur-Centre Hospitalier G. DRON Tourcoing, Tourcoing, France., Cheret A; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.; Department of Internal Medicine, Bicêtre Hospital, AP-HP, Le Kremlin-Bicêtre, France., Makinson A; Department of Infectious Diseases, Montpellier University Hospital, INSERM U1175/IRD UMI 233, Montpellier, France., Obry-Roguet V; Aix-Marseille Univ, APHM Sainte-Marguerite, Clinical Immuno-Hematological Unit Marseille, Marseille, France., Lions C; Aix-Marseille Univ, APHM Sainte-Marguerite, Clinical Immuno-Hematological Unit Marseille, Marseille, France., Carrieri MP; Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, France.; ORS PACA, Observatoire Régional De La Santé Provence-Alpes-Côte d'Azur, Marseille, France., Protopopescu C; Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, France.; ORS PACA, Observatoire Régional De La Santé Provence-Alpes-Côte d'Azur, Marseille, France.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Mar 25; Vol. 17 (3), pp. e0261069. Date of Electronic Publication: 2022 Mar 25 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0261069
Abstrakt: Background: We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program.
Setting: This is a retrospective study based on the longitudinal data of the French Dat'AIDS cohort.
Methods: Standardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection.
Results: The 2010-2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6-33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18-3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm3 (SIR = 2.62, 95% CI: 1.45-4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93-13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47-8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07-3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42-0.73).
Conclusion: The present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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