Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.

Autor:	Park BY; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.; Department of Data Science, Inha University, Incheon, Republic of Korea.; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea., Larivière S; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Rodríguez-Cruces R; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Royer J; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Tavakol S; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Wang Y; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Caciagli L; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Caligiuri ME; Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy., Gambardella A; Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.; Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy., Concha L; Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México., Keller SS; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; Walton Centre NHS Foundation Trust, Liverpool, UK., Cendes F; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Alvim MKM; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Yasuda C; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Bonilha L; Department of Neurology, Emory University, Atlanta, GA, USA., Gleichgerrcht E; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA., Focke NK; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Kreilkamp BAK; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Domin M; Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany., von Podewils F; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Langner S; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Rummel C; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland., Rebsamen M; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland., Wiest R; Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland., Martin P; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Kotikalapudi R; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Bender B; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., O'Brien TJ; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Law M; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia., Sinclair B; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Vivash L; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Kwan P; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Desmond PM; Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Malpas CB; Departments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Lui E; Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Alhusaini S; Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA., Doherty CP; Department of Neurology, St James' Hospital, Dublin, Ireland.; FutureNeuro SFI Research Centre, Dublin, Ireland., Cavalleri GL; Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro SFI Research Centre, Dublin, Ireland., Delanty N; Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro SFI Research Centre, Dublin, Ireland., Kälviäinen R; Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.; Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Jackson GD; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia., Kowalczyk M; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia., Mascalchi M; Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy., Semmelroch M; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia., Thomas RH; Transitional and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Soltanian-Zadeh H; Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.; Departments of Research Administration and Radiology, Henry Ford Health System, Detroit, MI, USA., Davoodi-Bojd E; Department of Neurology, Henry Ford Health System, Detroit, MI, USA., Zhang J; Department of Artificial Intelligence, Xiamen University, Xiamen, China., Lenge M; Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.; Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Guerrini R; Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Bartolini E; USL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy., Hamandi K; Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.; The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK., Foley S; Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK., Weber B; Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany., Depondt C; Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium., Absil J; Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium., Carr SJA; Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK., Abela E; Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK., Richardson MP; Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK., Devinsky O; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA., Severino M; IRCCS Istituto Giannina Gaslini, Genova, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Striano P; IRCCS Istituto Giannina Gaslini, Genova, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Parodi C; IRCCS Istituto Giannina Gaslini, Genova, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Tortora D; IRCCS Istituto Giannina Gaslini, Genova, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Hatton SN; Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA., Vos SB; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK.; Centre for Medical Image Computing, University College London, London, UK., Duncan JS; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK., Galovic M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK.; Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland., Whelan CD; Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland., Bargalló N; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Department of Radiology CDIC, Hospital Clinic Barcelona, Barcelona, Spain., Pariente J; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Conde-Blanco E; Epilepsy Unit, Department of Neurology, Hospital Clínic, Barcelona, Spain., Vaudano AE; Neurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy., Tondelli M; Neurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy., Meletti S; Neurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy., Kong XZ; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China., Francks C; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Fisher SE; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Caldairou B; Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Ryten M; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK., Labate A; Neurology, BIOMORF Department, University of Messina, Messina, Italy., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK., Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA., McDonald CR; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA., Bernasconi A; Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Bernasconi N; Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Bernhardt BC; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2022 May 24; Vol. 145 (4), pp. 1285-1298.
DOI:	10.1093/brain/awab417
Abstrakt:	Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy. (© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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