Impact of intrauterine growth restriction on cerebral and renal oxygenation and perfusion during the first 3 days after birth.

Autor: Montaldo P; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy. p.montaldo@imperial.ac.uk.; Centre for Perinatal Neuroscience, Level 5 Hammersmith House, Imperial College London, Du Cane Road, London, W12 0HS, UK. p.montaldo@imperial.ac.uk., Puzone S; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Caredda E; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Pugliese U; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Inserra E; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Cirillo G; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Gicchino F; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Campana G; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Ursi D; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Galdo F; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Internicola M; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Spagnuolo F; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Carpentieri M; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Capristo C; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Marzuillo P; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy., Del Giudice EM; Department of Neonatology, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Mar 24; Vol. 12 (1), pp. 5067. Date of Electronic Publication: 2022 Mar 24.
DOI: 10.1038/s41598-022-09199-5
Abstrakt: Intrauterine growth restriction (IUGR) is associated with a higher incidence of perinatal complications as well as cardiovascular and renal diseases later on. A better insight into the disease mechanisms underlying these sequalae is important in order to identify which IUGR infants are at a higher risk and find strategies to improve their outcome. In this prospective case-control study we examined whether IUGR had any effect on renal and cerebral perfusion and oxygen saturation in term neonates. We integrated near-infrared spectroscopy (NIRS), echocardiographic, Doppler and renal function data of 105 IUGR infants and 105 age/gender-matched controls. Cerebral and renal regional oxygen saturation values were measured by NIRS during the first 12 h after birth. Echocardiography alongside Doppler assessment of renal and anterior cerebral arteries were performed at 6, 24, 48 and 72 h of age. Glomerular and tubular functions were also assessed. We found a left ventricular dysfunction together with a higher cerebral oxygen saturation and perfusion values in the IUGR group. IUGR term infants showed a higher renal oxygen saturation and a reduced oxygen extraction together with a subclinical renal damage, as indicated by higher values of urinary neutrophil gelatinase-associated lipocalin and microalbumin. These data suggest that some of the haemodynamic changes present in growth-restricted foetuses may persist postnatally. The increased cerebral oxygenation may suggest an impaired transition to normal autoregulation as a consequence of intra-uterine chronic hypoxia. The higher renal oxygenation may reflect a reduced renal oxygen consumption due to a subclinical kidney damage.
(© 2022. The Author(s).)
Databáze: MEDLINE
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