Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water.

Autor: Waidyanatha S; Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States. Electronic address: waidyanathas@niehs.nih.gov., Weber FX; RTI International, Research Triangle Park, NC, United States., Fallacara DM; Battelle Memorial Institute, Columbus, OH, United States., Harrington JM; RTI International, Research Triangle Park, NC, United States., Levine K; RTI International, Research Triangle Park, NC, United States., Robinson VG; Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States., Sparrow BR; Battelle Memorial Institute, Columbus, OH, United States., Stout MD; Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States., Fernando R; RTI International, Research Triangle Park, NC, United States., Hooth MJ; Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States., Xie G; Social and Scientific Systems, Durham, NC, United States., Roberts GK; Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States.
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 2022 May 01; Vol. 360, pp. 53-61. Date of Electronic Publication: 2022 Mar 21.
DOI: 10.1016/j.toxlet.2022.03.004
Abstrakt: Vanadium is a ubiquitous environmental contaminant although there are limited data to assess potential adverse human health impact following oral exposure. In support of studies investigating the subchronic toxicity of vanadyl sulfate (V 4+ ) and sodium metavanadate (V 5+ ) following perinatal exposure via drinking water in male and female rats, we have determined the internal exposure and urinary excretion of total vanadium at the end of study. Water consumption decreased with increasing exposure concentration following exposure to both compounds. Plasma and urine vanadium concentration normalized to total vanadium consumed per day increased with the exposure concentration of vanadyl sulfate and sodium metavanadate suggesting absorption increased as the exposure concentration increased. Additionally, females had higher concentrations than males (in plasma only for vanadyl sulfate exposure). Animals exposed to sodium metavanadate had up to 3-fold higher vanadium concentration in plasma and urine compared to vanadyl sulfate exposed animals, when normalized to total vanadium consumed per day, demonstrating differential absorption, distribution, metabolism, and excretion properties between V 5+ and V 4+ compounds. These data will aid in the interpretation of animal toxicity data of V 4+ and V 5+ compounds and determine the relevance of animal toxicity findings to human exposures.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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