Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO).

Autor:	Tanrıverdi E; Clinic of Chest Diseases, University of Health Sciences Turkey, Yedikule Pulmonary Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey., Tutar N; Department of Pulmonary, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Şentürk A; Clinic of Pulmonary Diseases, University of Health Sciences Turkey, Atatürk Pulmonary Diseases and Thoracic Surgery Education and Research Hospital, Erzurum, Turkey., Bahadır A; Clinic of Chest Diseases, Başakşehir Çam and Sakura City Hospital, İstanbul, Turkey., Aksel N; Clinic of Chest Diseases, University of Health Sciences Turkey, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Yetkin NA; Department of Pulmonary, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Karadeniz G; Clinic of Chest Diseases, University of Health Sciences Turkey, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Çetin N; Deparment of Pulmonology, Faculty of Medicine, Pamukkale University, Denizli, Turkey., Tabaru A; Clinic of Pulmonology, Söke City Hospital, Aydın, Turkey., Yıldırım BZ; Clinic of Chest Diseases, University of Health Sciences Turkey, Yedikule Pulmonary Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey., Selimoğlu Şen H; Department of Chest Disease, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Özçelik N; Department of Pulmonology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey., Özsarı E; Department of Pulmonology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey., Uzer F; Clinic of Respiratory Disease, Kastamonu State Hospital, Kastamonu, Turkey., Çiçek T; Clinic of Chest Disease, Konya Numune Hospital, Konya, Turkey., Esendağlı D; Department of Pulmonology, Faculty of Medicine, Başkent University, Ankara, Turkey., Hocanlı İ; Department of Pulmonology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey., Durmuş Koçak N; Clinic of Chest Disease, Sancaktepe Şehit Prof. Dr. İlhan Varank Research and Training Hospital, İstanbul, Turkey., Tapan U; Department of Chest Diseases, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey., Kurt B; Clinic of Chest Disease, Dışkapı Education and Research Hospital, Ankara, Turkey., Arınç S; Clinic of Chest Diseases, University of Health Sciences Turkey, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey., Kavas M; Clinic of Chest Diseases, University of Health Sciences Turkey, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey., Şahin F; Clinic of Chest Diseases, University of Health Sciences Turkey, Yedikule Pulmonary Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey., Ergun D; Department of Chest Disease, Faculty of Medicine, Selçuk University, Konya, Turkey., Yılmazel Uçar E; Department of Chest Disease, Faculty of Medicine, Atatürk University, Erzurum, Turkey., Kılıç T; Department of Chest Disease, Faculty of Medicine, İnönü University, Malatya, Turkey., Gülmez İ; Department of Chest Disease, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Celdir Emre J; Clinic of Pulmonology, Turgutlu State Hospital, Manisa, Turkey., Doğan D; University of Health Sciences Turkey, Gülhane Training and Research Hospital, Ankara, Turkey., Özdemir F; Clinic of Pulmonology, Tekden Hospital, Kocaeli, Turkey., Düger M; Clinic of Chest Disease, İstanbul Medipol University, İstanbul, Turkey., Alzafer S; Clinic of Pulmonology, Bakırköy Acıbadem Hospital, İstanbul, Turkey., Yarar E; Clinic of Pulmonology, Necip Fazıl City Hospital, Kahramanmaraş, Turkey., Unat DS; Clinic of Chest Diseases, University of Health Sciences Turkey, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Salık B; Clinic of Chest Diseases, University of Health Sciences Turkey, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir, Turkey.
Jazyk:	angličtina
Zdroj:	Balkan medical journal [Balkan Med J] 2022 Mar 14; Vol. 39 (2), pp. 148-152.
DOI:	10.4274/balkanmedj.galenos.2021.2021-10-19
Abstrakt:	Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. Phase 3 study results have reported that these drugs are at least as effective as warfarin and beneficial in terms of bleeding; however, studies that present up-to-date life data are necessary. Aims: To evaluate the frequency of using DOACs, which are prescribed with a limited number of indications in our country, and real-life data results. Study Design: Cross-sectional study. Methods: This cross-sectional survey collected the clinical data (history, current treatment, treatment duration, etc.) of patients with pulmonary thromboembolism and who applied to the physician for follow-up between October 15, 2019, and March 15, 2020. The researchers kept the patient records sequentially. Results: Data from 836 patients with acute pulmonary thromboembolism from 25 centers were collected, and DOAC was used in 320 (38.5%) of them. The most preferred DOAC was rivaroxaban (n = 294, 91.9%). DOAC was mostly preferred because it could not provide an effective INR level with warfarin (n=133, 41.6%). Bleeding was observed in 13 (4%) patients. Conclusion: The use of direct oral anticoagulants is becoming almost as widespread as conventional therapy. Real-life data results are important for their contribution to clinical practice.
Databáze:	MEDLINE
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