| Autor: |
Szabó R; Department of Neurological Rehabilitation, Municipal Clinical Hospital, 410469 Oradea, Romania.; Doctoral School, Faculty of Medicine and Pharmacy, University of Oradea, 1 December Square, 410068 Oradea, Romania., Voiță-Mekereș F; Department of Morphology, Faculty of Medicine and Pharmacy, University of Oradea, 1 December Square, 410068 Oradea, Romania., Tudoran C; Department VII, Internal Medicine II, University of Medicine and Pharmacy 'Victor Babes' Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.; Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy 'Victor Babes' Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.; County Emergency Hospital, L. Rebreanu Str., Nr. 156, 300723 Timisoara, Romania., Abu-Awwad A; Department XV-Orthopedics Traumatology, Urology, and Medical Imaging Internal Medicine II, Faculty of Medicine, University of Medicine and Pharmacy 'Victor Babes' Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania., Tudoran M; Department VII, Internal Medicine II, University of Medicine and Pharmacy 'Victor Babes' Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.; Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy 'Victor Babes' Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.; County Emergency Hospital, L. Rebreanu Str., Nr. 156, 300723 Timisoara, Romania., Mihancea P; Doctoral School, Faculty of Medicine and Pharmacy, University of Oradea, 1 December Square, 410068 Oradea, Romania., Ilea CDN; Doctoral School, Faculty of Medicine and Pharmacy, University of Oradea, 1 December Square, 410068 Oradea, Romania. |
| Abstrakt: |
(1) Background: Based on the premise that epilepsy is frequently associated with hypnopathies, in this study we aim to analyze the prevalence of sleep disturbances among patients with epilepsy, with exclusively or predominantly nocturnal seizures, in relation to demographic factors as well as clinical and electroencephalography (EEG) aspects. (2) Methods: 69 patients with nocturnal epilepsy were included in our study. Sleep disturbances were measured with the Pittsburgh Sleep Quality Index (PSQI) questionnaire, followed by a long-term video-EEG monitoring during sleep. We analyzed the PSQI results in relation to patients' gender and age and determined the correlations between the PSQI scores and the modifications on video-EEG recordings, in comparison to a control group of 25 patients with epilepsy but without nocturnal seizures. (3) Results: We found a statistically significant difference between the PSQI of patients with nocturnal seizures compared to those without nocturnal epileptic manifestations. In the experimental group, the mean PSQI score was 7.36 ± 3.91 versus 5.04 ± 2.56 in controls. In women, the average PSQI score was 8.26, whilst in men it only reached 6.41, highlighting a statistically significant difference between genders ( p ˂ 0.01). By examining the relationships between the PSQI scores and certain sleep-related factors, evidenced on the nocturnal video-EEG, we found a statistically significant difference between PSQI values of patients who reached the N2 stage, and those who reached the N3 stage of nonrapid eye movement (NREM) sleep, highlighting that those with a more superficial nocturnal sleep also had higher PSQI scores. There were no statistically significant differences regarding the PSQI scores between patients with or without interictal epileptiform discharges, and also in the few patients with nocturnal seizures where we captured ictal activity. (4) Conclusions: we evidenced in this study a poor quality of sleep in patients with nocturnal epilepsy, mostly in women, independent of age. We observed that sleep disturbances were due to superficial and fragmented sleep with frequent microarousals, not necessarily caused by the electrical epileptiform activity. |
