Moderating effect of bone maturation on the relationship between body fat and insulin resistance.

Autor:	Flores L; Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua, México., Fragoso I; Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz Quebrada, Portugal., De León LG; Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua, México., Ortiz-Rodríguez B; Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua, México., Candia-Luján R; Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua, México., Carrasco-Legleu C; Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Chihuahua, México.
Jazyk:	angličtina
Zdroj:	Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2022 Mar 28; Vol. 35 (5), pp. 577-583. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022).
DOI:	10.1515/jpem-2021-0663
Abstrakt:	Objectives: The aim of the present study was to analyze the moderating effect of maturation on the relationship between body fat and insulin resistance, in children from 9 to 12 years. Methods: Maturity offset, homeostasis model assessment index of insulin resistance (HOMA-IR), and body fat percentage (BF%) were estimated in 127 children. Skeletal maturation indicator (SMI) was estimated in 105 participants. A moderation analysis based on a linear regression and on Johnson-Neyman technique was performed using a 95% confidence level. Results: BF%, insulin levels, and HOMA-IR values were lower in late maturers than on-time maturers (p<0.05). SMI moderated the relationship between BF% and HOMA-IR index in 11.1% of boys and in 32.5% of girls (p<0.05). Also, the highest values of HOMA-IR index were observed at -1 year to achieve the peak height velocity, in girls (p<0.05). Conclusions: Maturation process has a moderation effect on the relationship BF% and insulin resistance, particularly in early maturers; furthermore, it was independently associated with HOMA-IR. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu