The Underestimated and Overlooked Burden of Diarrhea and Constipation in Cancer Patients.

Autor: Moschen AR; Kepler University Hospital, Linz, Austria., Sammy Y; Nestlé Health Science, Vevey, Switzerland., Marjenberg Z; Maverex Ltd, Newcastle-upon-Tyne, UK., Heptinstall AB; Maverex Ltd, Newcastle-upon-Tyne, UK., Pooley N; Maverex Ltd, Newcastle-upon-Tyne, UK., Marczewska AM; Nestlé Health Science, Vevey, Switzerland. Agnieszka.Marczewska@nestle.com.
Jazyk: angličtina
Zdroj: Current oncology reports [Curr Oncol Rep] 2022 Jul; Vol. 24 (7), pp. 861-874. Date of Electronic Publication: 2022 Mar 24.
DOI: 10.1007/s11912-022-01267-3
Abstrakt: Purpose of Review: This review aims to summarize and discuss the diverse causes of two major gastrointestinal dysfunction symptoms, diarrhea and constipation, in cancer patients. We also discuss short- and long-term clinical, economic, and humanistic consequences, including the impact on cancer treatment regimens and patient quality of life, highlighting the limitations of the literature.
Recent Findings: Diarrhea and constipation as a result of cancer and its treatment can risk the success of anti-cancer therapies by requiring treatment delay or withdrawal, and imposes a substantial humanistic burden in patients with cancer. Despite its importance and frequency, gastrointestinal side effects may be overlooked due to the focus on cancer treatment, and the impact on patients may be underestimated. Additionally, the burden reported may not fully reflect current cancer management, particularly the true impact of economic consequences. A full understanding of the burden of diarrhea and constipation in patients with cancer is required, including broad evaluation of clinical considerations, the patient experience, and an updated assessment of economic burden. This would improve caregivers' appreciation of the impact of gastrointestinal dysfunction and aid the prioritization of future research efforts.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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