The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies.

Autor: Doak SH; Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK., Clift MJD; Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK., Costa A; Institute of Science and Technology for Ceramics, CNR-ISTEC-National Research Council of Italy, Faenza, Italy., Delmaar C; National Institute for Public Health and the Environment Netherlands, PO box 1, Bilthoven, 3720, the Netherlands., Gosens I; National Institute for Public Health and the Environment Netherlands, PO box 1, Bilthoven, 3720, the Netherlands., Halappanavar S; Environmental Health Science and Research Bureau, Health Canada, Ottawa, K1A0K9, Canada., Kelly S; Nanotechnology Industries Association, Avenue Tervueren 143, Brussels, 1150, Belgium., Pejinenburg WJGM; National Institute for Public Health and the Environment Netherlands, PO box 1, Bilthoven, 3720, the Netherlands.; Leiden University, PO Box 9518, Leiden, 2300 RA, the Netherlands., Rothen-Rutishauser B; Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, 1700, Switzerland., Schins RPF; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Düsseldorf, Germany., Stone V; School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK., Tran L; Institute of Occupational Medicine (IOM), Edinburgh, Scotland, EH14 4AP, UK., Vijver MG; Leiden University, PO Box 9518, Leiden, 2300 RA, the Netherlands., Vogel U; National Research Centre for the Working Environment, Copenhagen, DK-2100, Denmark., Wohlleben W; Advanced Materials Research, BASF SE, 67056, Ludwigshafen, Germany., Cassee FR; National Institute for Public Health and the Environment Netherlands, PO box 1, Bilthoven, 3720, the Netherlands.; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Apr; Vol. 18 (17), pp. e2200231. Date of Electronic Publication: 2022 Mar 24.
DOI: 10.1002/smll.202200231
Abstrakt: The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.
(© 2022 The Authors. Small published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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