A Novel Diagnostic Decision Support System for Medical Professionals: Prospective Feasibility Study.

Autor:	Timiliotis J; CMIO Research Group, Digitalization & ICT Department, University Hospital Basel, Basel, Switzerland., Blümke B; CMIO Research Group, Digitalization & ICT Department, University Hospital Basel, Basel, Switzerland.; Ada Health GmbH, Berlin, Germany., Serfözö PD; CMIO Research Group, Digitalization & ICT Department, University Hospital Basel, Basel, Switzerland., Gilbert S; Ada Health GmbH, Berlin, Germany.; Else Kröner Fresenius Center for Digital Health, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany., Ondrésik M; Ada Health GmbH, Berlin, Germany., Türk E; Ada Health GmbH, Berlin, Germany., Hirsch MC; Ada Health GmbH, Berlin, Germany.; Institute for Artificial Intelligence in Medicine, Philipps University of Marburg, Marburg, Germany., Eckstein J; CMIO Research Group, Digitalization & ICT Department, University Hospital Basel, Basel, Switzerland.; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Jazyk:	angličtina
Zdroj:	JMIR formative research [JMIR Form Res] 2022 Mar 24; Vol. 6 (3), pp. e29943. Date of Electronic Publication: 2022 Mar 24.
DOI:	10.2196/29943
Abstrakt:	Background: Continuously growing medical knowledge and the increasing amount of data make it difficult for medical professionals to keep track of all new information and to place it in the context of existing information. A variety of digital technologies and artificial intelligence-based methods are currently available as persuasive tools to empower physicians in clinical decision-making and improve health care quality. A novel diagnostic decision support system (DDSS) prototype developed by Ada Health GmbH with a focus on traceability, transparency, and usability will be examined more closely in this study. Objective: The aim of this study is to test the feasibility and functionality of a novel DDSS prototype, exploring its potential and performance in identifying the underlying cause of acute dyspnea in patients at the University Hospital Basel. Methods: A prospective, observational feasibility study was conducted at the emergency department (ED) and internal medicine ward of the University Hospital Basel, Switzerland. A convenience sample of 20 adult patients admitted to the ED with dyspnea as the chief complaint and a high probability of inpatient admission was selected. A study physician followed the patients admitted to the ED throughout the hospitalization without interfering with the routine clinical work. Routinely collected health-related personal data from these patients were entered into the DDSS prototype. The DDSS prototype's resulting disease probability list was compared with the gold-standard main diagnosis provided by the treating physician. Results: The DDSS presented information with high clarity and had a user-friendly, novel, and transparent interface. The DDSS prototype was not perfectly suited for the ED as case entry was time-consuming (1.5-2 hours per case). It provided accurate decision support in the clinical inpatient setting (average of cases in which the correct diagnosis was the first diagnosis listed: 6/20, 30%, SD 2.10%; average of cases in which the correct diagnosis was listed as one of the top 3: 11/20, 55%, SD 2.39%; average of cases in which the correct diagnosis was listed as one of the top 5: 14/20, 70%, SD 2.26%) in patients with dyspnea as the main presenting complaint. Conclusions: The study of the feasibility and functionality of the tool was successful, with some limitations. Used in the right place, the DDSS has the potential to support physicians in their decision-making process by showing new pathways and unintentionally ignored diagnoses. The DDSS prototype had some limitations regarding the process of data input, diagnostic accuracy, and completeness of the integrated medical knowledge. The results of this study provide a basis for the tool's further development. In addition, future studies should be conducted with the aim to overcome the current limitations of the tool and study design. Trial Registration: ClinicalTrials.gov NCT04827342; https://clinicaltrials.gov/ct2/show/NCT04827342. (©Joanna Timiliotis, Bibiana Blümke, Peter Daniel Serfözö, Stephen Gilbert, Marta Ondrésik, Ewelina Türk, Martin Christian Hirsch, Jens Eckstein. Originally published in JMIR Formative Research (https://formative.jmir.org), 24.03.2022.)
Databáze:	MEDLINE
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