Retrospective evaluation of hypertrophic cardiomyopathy in 68 dogs.

Autor: Schober KE; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA., Fox PR; Department of Cardiology, The Animal Medical Center, New York, New York, USA., Abbott J; Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, Tennessee, USA., Côté E; Ecole Nationale Vétérinaire d'Alfort, Unite de Cardiologie d'Alfort (UCA), Université Paris-Est, Maisons-Alfort, France., Luis-Fuentes V; Clinical Sciences and Services, Royal Veterinary College, London, UK., Matos JN; Clinical Sciences and Services, Royal Veterinary College, London, UK.; Clinic for Small Animal Internal Medicine, University of Zürich, Zürich, Switzerland., Stern JA; Department of Medicine and Epidemiology, University of California, Davis, California, USA., Visser L; Department of Medicine and Epidemiology, University of California, Davis, California, USA., Scollan KF; Department of Clinical Sciences, Oregon State University, Corvallis, Oregon, USA., Chetboul V; Atlantic Veterinary College, University of Prince Edward Island, Prince Edward Island, Canada., Schrope D; Department of Cardiology, Oradell Animal Hospital, Paramus, New Jersey, USA., Glaus T; Clinic for Small Animal Internal Medicine, University of Zürich, Zürich, Switzerland., Santilli R; Clinica Veterinaria Malpensa, Samarate-Varese, Italy., Pariaut R; Department of Clinical Sciences, Cornell College of Veterinary Medicine, Ithaca, New York, USA., Stepien R; Department of Medical Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, USA., Arqued-Soubeyran V; Ecole Nationale Vétérinaire d'Alfort, Unite de Cardiologie d'Alfort (UCA), Université Paris-Est, Maisons-Alfort, France., Baron Toaldo M; Clinic for Small Animal Internal Medicine, University of Zürich, Zürich, Switzerland., Estrada A; Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA., MacDonald K; VCA Animal Care Center, Rohnert Park, California, USA., Karlin ET; Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA., Rush J; Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2022 May; Vol. 36 (3), pp. 865-876. Date of Electronic Publication: 2022 Mar 24.
DOI: 10.1111/jvim.16402
Abstrakt: Background: There is a lack of clinical data on hypertrophic cardiomyopathy (HCM) in dogs.
Hypothesis/objectives: To investigate signalment, clinical signs, diagnostic findings, and survival in dogs with HCM.
Animals: Sixty-eight client-owned dogs.
Methods: Retrospective multicenter study. Medical records were searched between 2003 and 2015. The diagnosis of left ventricular (LV) hypertrophy was made by echocardiographic examination.
Results: Three hundred and forty-five dogs with LV hypertrophy were identified, of which 277 were excluded. The remaining 68 dogs were 0.3 to 14 years old and predominantly <10 kg (85%), and without a sex predilection. Twenty-four % were Shih Tzu and 24% terrier breeds. Most (80%) had a systolic heart murmur. Owner-determined exercise intolerance (37%) and syncope (18%) were most commonly reported signs. The majority (84%) of dogs had symmetrical LV hypertrophy, whereas asymmetrical septal and LV free wall hypertrophy was observed in 9% and 6% of dogs, respectively. Isolated basal interventricular septal hypertrophy was not observed. Commonly recorded were systolic anterior motion of the mitral valve (60%) and LV diastolic dysfunction (89% of dogs where diastolic function was evaluated). Six dogs died unexpectedly, and 3 developed congestive heart failure. Known survival times were between 1 day and 114 months after diagnosis.
Conclusions and Clinical Importance: Hypertrophic cardiomyopathy in dogs should be considered as a differential diagnosis if LV hypertrophy is identified. Small breed dogs are overrepresented, and it is uncommon for dogs with HCM to develop CHF although sudden death can occur.
(© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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