Applicability of nanomaterial-specific guidelines within long-term Daphnia magna toxicity assays: A case study on multigenerational effects of nTiO 2 and nCeO 2 exposure in the presence of artificial daylight.

Autor: Nederstigt TAP; Institute of Environmental Sciences, University of Leiden, Leiden, the Netherlands. Electronic address: t.a.p.nederstigt@cml.leidenuniv.nl., Peijnenburg WJGM; Institute of Environmental Sciences, University of Leiden, Leiden, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Bleeker EAJ; National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Vijver MG; Institute of Environmental Sciences, University of Leiden, Leiden, the Netherlands.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2022 Jun; Vol. 131, pp. 105156. Date of Electronic Publication: 2022 Mar 20.
DOI: 10.1016/j.yrtph.2022.105156
Abstrakt: In recent years, various ecotoxicological test guidelines and (technical) guidance documents have been evaluated and updated with regard to their applicability to nanomaterials (NMs). Several of these have currently reached official regulatory status. Ensuring their harmonized implementation with previously recognized methods for ecotoxicity testing of chemicals is a crucial next step towards effective and efficient regulation of NMs. In the present study, we evaluated the feasibility of assessing multigenerational effects in the first generation of offspring derived from exposed Daphnia magna whilst maintaining test conditions in accordance with regulatory test guidelines and guidance documents for NMs. To do so, we integrated the recommendations for ecotoxicological testing of NMs as defined in OECD Guidance Document 317 into an extended long-term D. magna reproduction test method (OECD Test Guideline 211) and assessed effects of two poorly soluble NMs (nTiO 2 and nCeO 2 ). Our results show adverse effects on life-history parameters of D. magna exposed to the selected nanomaterials within the range of reported environmental concentrations. We argue that conforming to OECD test guidelines and accompanying guidance for nanomaterials is feasible when performing D. magna reproduction tests and can minimize unnecessary duplication of similar experiments, even when extensions to the standardized test setup are added.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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