The Purinosome: A Case Study for a Mammalian Metabolon.

Autor:	Pedley AM; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA; email: sjb1@psu.edu., Pareek V; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA; email: sjb1@psu.edu.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA., Benkovic SJ; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA; email: sjb1@psu.edu.
Jazyk:	angličtina
Zdroj:	Annual review of biochemistry [Annu Rev Biochem] 2022 Jun 21; Vol. 91, pp. 89-106. Date of Electronic Publication: 2022 Mar 23.
DOI:	10.1146/annurev-biochem-032620-105728
Abstrakt:	Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex called the purinosome. In this review, we highlight our current understanding of the purinosome with emphasis on its biophysical properties and function and on the cellular mechanisms that regulate its assembly. We propose a model for functional purinosomes in which they consist of at least ten enzymes that localize near mitochondria and carry out de novo purine biosynthesis by metabolic channeling. We conclude by discussing challenges and opportunities associated with studying the purinosome and analogous metabolons.
Databáze:	MEDLINE
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