Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C.
| Autor: | Al-Antary ET; Division of Pediatric Hematology Oncology, Department of Pediatrics., Arar R; Division of Pediatric Hematology Oncology, Department of Pediatrics., Persaud Y; Division of Pediatric Hematology Oncology, Department of Pediatrics., Fathalla BM; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University College of Medicine, Detroit, MI., Rajpurkar M; Division of Pediatric Hematology Oncology, Department of Pediatrics., Bhambhani K; Division of Pediatric Hematology Oncology, Department of Pediatrics. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2022 Apr 01; Vol. 44 (3), pp. e812-e815. |
| DOI: | 10.1097/MPH.0000000000002370 |
| Abstrakt: | The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE. Competing Interests: The authors declare no conflict of interest. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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