EEG functional connectivity is sensitive for nitrogen narcosis at 608 kPa.

Autor: Vrijdag XCE; Department of Anaesthesiology, School of Medicine, University of Auckland, Private bag 92019, Auckland, 1142, New Zealand. x.vrijdag@auckland.ac.nz., van Waart H; Department of Anaesthesiology, School of Medicine, University of Auckland, Private bag 92019, Auckland, 1142, New Zealand., Pullon RM; Department of Anaesthesiology, School of Medicine, University of Auckland, Private bag 92019, Auckland, 1142, New Zealand.; Department of Anaesthesia, Waikato Hospital, Hamilton, 3240, New Zealand., Sames C; Slark Hyperbaric Unit, Waitemata District Health Board, Auckland, 0610, New Zealand., Mitchell SJ; Department of Anaesthesiology, School of Medicine, University of Auckland, Private bag 92019, Auckland, 1142, New Zealand.; Slark Hyperbaric Unit, Waitemata District Health Board, Auckland, 0610, New Zealand.; Department of Anaesthesia, Auckland City Hospital, Auckland, 1023, New Zealand., Sleigh JW; Department of Anaesthesiology, School of Medicine, University of Auckland, Private bag 92019, Auckland, 1142, New Zealand.; Department of Anaesthesia, Waikato Hospital, Hamilton, 3240, New Zealand.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Mar 22; Vol. 12 (1), pp. 4880. Date of Electronic Publication: 2022 Mar 22.
DOI: 10.1038/s41598-022-08869-8
Abstrakt: Divers commonly breathe air, containing nitrogen. Nitrogen under hyperbaric conditions is a narcotic gas. In dives beyond a notional threshold of 30 m depth (405 kPa) this can cause cognitive impairment, culminating in accidents due to poor decision making. Helium is known to have no narcotic effect. This study explored potential approaches to developing an electroencephalogram (EEG) functional connectivity metric to measure narcosis produced by nitrogen at hyperbaric pressures. Twelve human participants (five female) breathed air and heliox (in random order) at 284 and 608 kPa while recording 32-channel EEG and psychometric function. The degree of spatial functional connectivity, estimated using mutual information, was summarized with global efficiency. Air-breathing at 608 kPa (experienced as mild narcosis) caused a 35% increase in global efficiency compared to surface air-breathing (mean increase = 0.17, 95% CI [0.09-0.25], p = 0.001). Air-breathing at 284 kPa trended in a similar direction. Functional connectivity was modestly associated with psychometric impairment (mixed-effects model r 2  = 0.60, receiver-operating-characteristic area, 0.67 [0.51-0.84], p = 0.02). Heliox breathing did not cause a significant change in functional connectivity. In conclusion, functional connectivity increased during hyperbaric air-breathing in a dose-dependent manner, but not while heliox-breathing. This suggests sensitivity to nitrogen narcosis specifically.
(© 2022. The Author(s).)
Databáze: MEDLINE
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