[Biochemical analysis of an uncommon monoclonal peak on urine protein electrophoresis: a case report].
| Autor: | Bissan ADT; Centre d'Infectiologie Charles Mérieux, Bamako, Mali.; Université des Sciences, des Techniques, des Technologies de Bamako, Faculté de Pharmacie, Bamako, Mali., Karfo R; Unité de Formation et de Recherche (UFR) Sciences de la Santé, Université Ouaga Joseph KI-ZERBO, Ouagadougou, Burkina Faso., Diawara A; Laboratoire d´Analyses Médicales Algi, Quinzambougou, Bamako, Mali., Tekete A; Laboratoire d´Analyses Médicales Algi, Quinzambougou, Bamako, Mali., Tangara O; Laboratoire d´Analyses Médicales Algi, Quinzambougou, Bamako, Mali. |
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| Jazyk: | francouzština |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2022 Jan 19; Vol. 41, pp. 53. Date of Electronic Publication: 2022 Jan 19 (Print Publication: 2022). |
| DOI: | 10.11604/pamj.2022.41.53.25726 |
| Abstrakt: | Urine protein electrophoresis is often required for diagnosis and monitoring of urological or renal diseases and lymphoid hemopathies. We here report an uncommon urine protein electrophoresis result. The test was performed using agarose gel electrophoresis and capillary electrophoresis. It was a monoclonal peak of unknown significance migrating with gammaglobulins. Scientific literature and the tests performed demonstrated that it was myoglobin. In fact, myoglobin (17 kDa) is freely filtered by the glomerulus and normally reabsorbed by the tubules. If tubule capacity for reabsorption is exceeded, its presence results in overcharging proteinuria. Myoglobinuria helped diagnose rhabdomyolysis in our patient. Thus, the analysis of unknown peaks, can provide information on symptoms but also underlying pathologies, which may be of clinical interest. Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêts. (Copyright: Aboubacar Dit Tietie Bissan et al.) |
| Databáze: | MEDLINE |
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