Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori -negative Ménétrier's disease: A case report.

Autor:	Fukushi K; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Goda K; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan. goda@dokkyomed.ac.jp., Kino H; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Kondo M; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Kanazawa M; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Kashima K; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Kanamori A; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Abe K; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Suzuki T; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Tominaga K; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Yamagishi H; Department of Diagnostic Pathology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan., Irisawa A; Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2022 Feb 07; Vol. 28 (5), pp. 594-601.
DOI:	10.3748/wjg.v28.i5.594
Abstrakt:	Background: Adult-onset Ménétrier's disease is strongly associated with Helicobacter pylori ( H. pylori ) infection and an elevated risk of carcinogenesis. Cases of early-stage gastric cancer developed in H. pylori -negative Ménétrier's disease are extremely rare. We report a case of early gastric cancer in H. pylori -negative Ménétrier's disease that was curatively resected with endoscopic submucosal dissection (ESD). Case Summary: A 60-year-old woman was referred to our hospital after her medical examination detected anemia. Contrast-enhanced upper gastrointestinal (UGI) radiography revealed translucency of the nodule-aggregating surface with giant rugae. Blood tests showed hypoproteinemia and were negative for serum H. pylori immunoglobulin G antibodies. The 99m Tc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach. UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body, suggesting early-stage gastric cancer due to Ménétrier's disease. En bloc resection with ESD was performed for diagnosis and treatment. Histology of ESD showed well-differentiated tubular adenocarcinoma. The cancer was confined to the mucosa, and complete curative resection was achieved. Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas, histologically corresponding to Ménétrier's disease. Three years after ESD, gastric cancer had not recurred, and Ménétrier's disease remained in remission with spontaneous regression of giant gastric rugae. Conclusion: Complete curative resection was achieved through ESD in a patient with early-stage gastric cancer and H. pylori -negative Ménétrier's disease. Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu