Microwave Ablation for Malignant Central Airway Obstruction: A Pilot Study.

Autor:	Senitko M; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Division of Cardiothoracic Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Oberg CL; Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Abraham GE; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hillegass WB; Departments of Data Science and Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Akhtar I; Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Department of Pathology and Laboratory Medicine, Temple University Health System, Philadelphia, Pennsylvania, USA., Folch E; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	Respiration; international review of thoracic diseases [Respiration] 2022; Vol. 101 (7), pp. 666-674. Date of Electronic Publication: 2022 Mar 22.
DOI:	10.1159/000522544
Abstrakt:	Background: Malignant central airway obstruction (CAO) is a debilitating complication of primary lung cancer and pulmonary metastases. Therapeutic bronchoscopy is used to palliate symptoms and/or bridge to further therapy. Microwave ablation (MWA) heats tissue by creating an electromagnetic field around an ablation device. We present a pilot study utilizing endobronchial MWA via flexible bronchoscopy as a novel modality for the management of malignant CAO. Methods: Therapeutic bronchoscopy with a flexible MWA probe was performed in 8 cases. We reviewed tumor size, previous ablative techniques, number of applications, ablation time, amount of energy delivered, rate of successful recanalization, complications, and 30-day follow-up. Results: Successful airway recanalization was achieved in all cases. No complications were noted. In 1 case, tumor in-growth within a silicone stent was ablated with no damage to the stent. Discussion: Endobronchial MWA is a novel technique for tumor destruction while maintaining an airway axis. The oven effect and air gap around a tumor allow for safe and effective tissue devitalization and hemostasis without a thermal effect on structures surrounding the airway. (© 2022 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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