| Autor: |
Rebelo KS; Department of Food and Nutrition, School of Food Engineering, University of Campinas, C.P. 6121, 13083-862, Campinas, SP, Brazil. kemillasr@ufam.edu.br.; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark., Nunez CEC; Department of Food and Nutrition, School of Food Engineering, University of Campinas, C.P. 6121, 13083-862, Campinas, SP, Brazil. kemillasr@ufam.edu.br.; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark., Cazarin CBB; Department of Food and Nutrition, School of Food Engineering, University of Campinas, C.P. 6121, 13083-862, Campinas, SP, Brazil. kemillasr@ufam.edu.br., Maróstica Júnior MR; Department of Food and Nutrition, School of Food Engineering, University of Campinas, C.P. 6121, 13083-862, Campinas, SP, Brazil. kemillasr@ufam.edu.br., Kristiansen K; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark., Danneskiold-Samsøe NB; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. |
| Abstrakt: |
Pot-pollen is a mixture of pollen and nectar from flowers combined with salivary substances of stingless bees, which together are fermented inside cerumen pots. As pot-pollen is rich in polyphenols, we hypothesized that dietary ingestion could modulate obesity, glucose metabolism, and the gut microbiota in an animal model of diet-induced obesity. Male C57BL/6J mice were fed a low-fat/low-sucrose diet (LF/LS), a HF/HS diet or a HF/HS diet containing 0.1% pot-pollen (HF/HS-PP) for 12 weeks. In HF/HS-fed mice, pot-pollen supplementation decreased fasting blood glucose and increased glucose-stimulated insulin secretion without modifying weight gain, body composition, glucose tolerance, and insulin sensitivity. Intake of pot-pollen resulted in changes of the gut microbiota, including a decrease in the abundance of the Rikenellaceae RC9 gut group and Lactobacillus , and an increase in the abundance of Romboutsia . Correlations between genus abundances and metabolic changes in response to supplementation indicated that the gut microbiota contributed to the positive effects of pot-pollen ingestion on fasting glucose. Pot-pollen supplementation-associated changes in the gut microbiota composition correlated with the lowering of fasting glucose levels without modulating weight gain. |
