KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma.

Autor:	Lee BC; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Departments of Medical Imaging, National Taiwan University Hospital Yun-lin Branch, Douliu, Taiwan., Kang VJ; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan., Pan CT; Departments of Internal Medicine, National Taiwan University Hospital Yun-lin Branch, Douliu, Taiwan., Huang JZ; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan., Lin YL; Department of Business Administration and Graduate School of Service Management, Chihlee University of Technology, New Taipei City, Taiwan., Chang YY; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Tsai CH; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chou CH; Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan., Chen ZW; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Departments of Internal Medicine, National Taiwan University Hospital Yun-lin Branch, Douliu, Taiwan., Liao CW; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, HsinChu, Taiwan., Chiu YW; Department of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.; Department of Computer Science and Engineering, Yuan Ze University, Taoyuan City, Taiwan., Wu VC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Hung CS; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan., Chang CC; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan., Lin YH; Department of Business Administration and Graduate School of Service Management, Chihlee University of Technology, New Taipei City, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Mar 02; Vol. 13, pp. 830130. Date of Electronic Publication: 2022 Mar 02 (Print Publication: 2022).
DOI:	10.3389/fendo.2022.830130
Abstrakt:	Objective: Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status. Methods: We enrolled 179 APA patients who had undergone adrenalectomy from a prospectively maintained database, of whom 99 had KCNJ5 somatic mutations. Preoperative clinical, biochemical and imaging data of abdominal CT, including abdominal aortic calcification (AAC) score, aortic diameter and wall thickness at levels of superior (SMA) and inferior (IMA) mesenteric arteries were analyzed. Results: After propensity score matching for age, sex, body mass index, triglycerides and low-density lipoprotein, there were 48 patients in each KCNJ5 (+) and KCNJ5 (-) group. Mutation carriers had a lower AAC score (217.3 ± 562.2 vs. 605.6 ± 1359.1, P=0.018), higher aortic wall thickness (SMA level: 2.2 ± 0.6 mm vs. 1.8 ± 0.6 mm, P=0.006; IMA level: 2.4 ± 0.6 mm vs. 1.8 ± 0.7 mm, P<0.001) than non-carriers. In multivariate analysis, KCNJ5 mutations were independently associated with AAC score (P=0.014) and aortic wall thickness (SMA level: P<0.001; IMA level: P=0.004). After adrenalectomy, mutation carriers had less aortic wall thickness progression than non-carriers (Δthickness SMA: -0.1 ± 0.8 mm vs. 0.9 ± 0.6 mm, P=0.024; IMA: -0.1 ± 0.6 mm vs. 0.8 ± 0.7 mm, P=0.04). Conclusion: KCNJ5 mutation carriers had less calcification burden of the aorta, thickened aortic wall, and less wall thickness progression than non-carriers. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lee, Kang, Pan, Huang, Lin, Chang, Tsai, Chou, Chen, Liao, Chiu, Wu, Hung, Chang and Lin.)
Databáze:	MEDLINE
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