Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.

Autor:	Hishida T; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.; Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan., Vazquez-Ferrer E; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Hishida-Nozaki Y; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Takemoto Y; Department of Basic Medical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan., Hatanaka F; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Yoshida K; Department of Basic Medical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan., Prieto J; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Sahu SK; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Takahashi Y; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Reddy P; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., O'Keefe DD; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Rodriguez Esteban C; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States., Knoepfler PS; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, United States., Nuñez Delicado E; Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Murcia, Spain., Castells A; Gastroenterology Department, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona, Spain., Campistol JM; Gastroenterology Department, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona, Spain., Kato R; Department of Basic Medical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan., Nakagawa H; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, United States.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States., Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Mar 04; Vol. 10, pp. 786031. Date of Electronic Publication: 2022 Mar 04 (Print Publication: 2022).
DOI:	10.3389/fcell.2022.786031
Abstrakt:	It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Hishida, Vazquez-Ferrer, Hishida-Nozaki, Takemoto, Hatanaka, Yoshida, Prieto, Sahu, Takahashi, Reddy, O’Keefe, Rodriguez Esteban, Knoepfler, Nuñez Delicado, Castells, Campistol, Kato, Nakagawa and Izpisua Belmonte.)
Databáze:	MEDLINE
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