Cell Hypertrophy: A "Biophysical Roadblock" to Reversing Kidney Injury.
| Autor: | Lavecchia AM; Laboratory of Organ Regeneration, Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Bergamo, Italy., Pelekanos K; Independent scholar, Nicosia, Cyprus., Mavelli F; Department of Chemistry, University of Bari Aldo Moro, Bari, Italy., Xinaris C; Laboratory of Organ Regeneration, Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Bergamo, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Mar 03; Vol. 10, pp. 854998. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022). |
| DOI: | 10.3389/fcell.2022.854998 |
| Abstrakt: | In anamniotes cell loss can typically be compensated for through proliferation, but in amniotes, this capacity has been significantly diminished to accommodate tissue complexity. In order to cope with the increased workload that results from cell death, instead of proliferation highly specialised post-mitotic cells undergo polyploidisation and hypertrophy. Although compensatory hypertrophy is the main strategy of repair/regeneration in various parenchymal tissues, the long-term benefits and its capacity to sustain complete recovery of the kidney has not been addressed sufficiently. In this perspective article we integrate basic principles from biophysics and biology to examine whether renal cell hypertrophy is a sustainable adaptation that can efficiently regenerate tissue mass and restore organ function, or a maladaptive detrimental response. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lavecchia, Pelekanos, Mavelli and Xinaris.) |
| Databáze: | MEDLINE |
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