Rational development and application of biomarkers in the field of autoimmunity: A conceptual framework guiding clinicians and researchers.
| Autor: | Kolev M; Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital Bern, University of Bern, Bern, Switzerland., Horn MP; Departement of Clinical Chemistry, Inselspital Bern, University of Bern, Bern, Switzerland., Semmo N; Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital Bern, University of Bern, Bern, Switzerland., Nagler M; Departement of Clinical Chemistry, Inselspital Bern, University of Bern, Bern, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of translational autoimmunity [J Transl Autoimmun] 2022 Mar 06; Vol. 5, pp. 100151. Date of Electronic Publication: 2022 Mar 06 (Print Publication: 2022). |
| DOI: | 10.1016/j.jtauto.2022.100151 |
| Abstrakt: | Clear guidance is needed in the development and implementation of laboratory biomarkers in medicine. So far, no standardized phased approach is established that would pilot researchers and clinicians in this process. This leads to often incompletely validated biomarkers, which can bear the consequence of wrong applications, misinterpretation and inadequate management in the clinical context. In this conceptual article, we describe a stepwise approach to develop and comprehensively validate laboratory biomarkers. We will delineate basic steps including technical performance, pre-analytical issues, and biological variation, as well as advanced aspects of biomarker utility comprising interpretability, diagnostic and prognostic accuracy, and health-care outcomes. These aspects will be illustrated by using well-known examples from the field of immunology. The application of this conceptual framework will guide researchers in conducting meaningful projects to develop and evaluate biomarkers for the use in clinical practice. Furthermore, clinicians will be able to adequately interpret pre-clinical and clinical diagnostic literature and rationally apply biomarkers in clinical practice. Improvement in the implementation and application of biomarkers might relevantly change the management and outcomes of our patients for the better. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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