ROS-Scavenging Selenofluoxetine Derivatives Inhibit In Vivo Serotonin Reuptake.

Autor:	Ribaudo G; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Viale Europa 11, 25123 Brescia, Italy., Bortoli M; Dipartimento di Scienze Chimiche, Università degli Studi di Padova Via Marzolo 1, 35131 Padova, Italy.; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, c/Maria Aurèlia Capmany 69, 17003 Girona, Catalonia, Spain., Witt CE; Department of Chemistry and Biochemistry, University of South Carolina, Columbia South Carolina 29201, United States., Parke B; Department of Bioengineering, Imperial College London, London SW7 2AZ, U.K., Mena S; Department of Bioengineering, Imperial College London, London SW7 2AZ, U.K., Oselladore E; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Viale Europa 11, 25123 Brescia, Italy., Zagotto G; Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Via Marzolo 5, 35131 Padova, Italy., Hashemi P; Department of Bioengineering, Imperial College London, London SW7 2AZ, U.K.; Department of Chemistry and Biochemistry, University of South Carolina, Columbia South Carolina 29201, United States., Orian L; Dipartimento di Scienze Chimiche, Università degli Studi di Padova Via Marzolo 1, 35131 Padova, Italy.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2022 Mar 02; Vol. 7 (10), pp. 8314-8322. Date of Electronic Publication: 2022 Mar 02 (Print Publication: 2022).
DOI:	10.1021/acsomega.1c05567
Abstrakt:	While the neurochemistry that underpins the behavioral phenotypes of depression is the subject of many studies, oxidative stress caused by the inflammation comorbid with depression has not adequately been addressed. In this study, we described novel antidepressant-antioxidant agents consisting of selenium-modified fluoxetine derivatives to simultaneously target serotonin reuptake (antidepressant action) and oxidative stress. Excitingly, we show that one of these agents ( 1-F ) carries the ability to inhibit serotonin reuptake in vivo in mice. We therefore present a frontier dual strategy that paves the way for the future of antidepressant therapies. Competing Interests: The authors declare no competing financial interest. (© 2022 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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