Iron-catalyzed intermolecular cross-dehydrogenative C(sp 3 )-H/C(sp)-H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes.

Autor: Morja MI; Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India., Chikhalia KH; Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India. chikhalia_kh@yahoo.com.
Jazyk: angličtina
Zdroj: Molecular diversity [Mol Divers] 2022 Dec; Vol. 26 (6), pp. 3037-3045. Date of Electronic Publication: 2022 Mar 20.
DOI: 10.1007/s11030-021-10363-8
Abstrakt: A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones systems and terminal alkynes was established. This methodology offers a high yielding, straightforward, and one-pot approach towards the synthesis of alkynylated 4-thiazolidinones without prior activation of C(sp 3 )-H and C(sp)-H. The results of control experiments indicated that this conversion might proceed via a radical process.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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