Iron-catalyzed intermolecular cross-dehydrogenative C(sp 3 )-H/C(sp)-H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes.
Autor: | Morja MI; Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India., Chikhalia KH; Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India. chikhalia_kh@yahoo.com. |
---|---|
Jazyk: | angličtina |
Zdroj: | Molecular diversity [Mol Divers] 2022 Dec; Vol. 26 (6), pp. 3037-3045. Date of Electronic Publication: 2022 Mar 20. |
DOI: | 10.1007/s11030-021-10363-8 |
Abstrakt: | A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones systems and terminal alkynes was established. This methodology offers a high yielding, straightforward, and one-pot approach towards the synthesis of alkynylated 4-thiazolidinones without prior activation of C(sp 3 )-H and C(sp)-H. The results of control experiments indicated that this conversion might proceed via a radical process. (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
Databáze: | MEDLINE |
Externí odkaz: |