Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.

Autor:	Sun D; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina., Rakesh G; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina., Clarke-Rubright EK; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina., Haswell CC; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina., Logue MW; National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts; Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., O'Leary EN; Department of Psychiatry, University of Toledo, Toledo, Ohio., Cotton AS; Department of Psychiatry, University of Toledo, Toledo, Ohio., Xie H; Department of Psychiatry, University of Toledo, Toledo, Ohio., Dennis EL; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California; Stanford Neurodevelopment, Affect, and Psychopathology Laboratory, Stanford, California; Department of Neurology, University of Utah, Salt Lake City, Utah., Jahanshad N; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Salminen LE; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Thomopoulos SI; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Rashid FM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Ching CRK; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Koch SBJ; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands., Frijling JL; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Nawijn L; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van Zuiden M; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Zhu X; Department of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York., Suarez-Jimenez B; Department of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York; University of Rochester Medical Center, Rochester, New York., Sierk A; University Medical Centre Charité, Berlin, Germany., Walter H; University Medical Centre Charité, Berlin, Germany., Manthey A; University Medical Centre Charité, Berlin, Germany., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Stein MB; Department of Psychiatry, University of California San Diego, San Diego, California., Bomyea J; Department of Psychiatry, University of California San Diego, San Diego, California., Koerte I; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Choi K; Health Services Research Center, University of California San Diego, San Diego, California., van der Werff SJA; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., Vermeiren RRJM; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands., Herzog JI; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Depression and Anxiety Disorders, McLean Hospital, Harvard University, Belmont, Massachusetts., Baker JT; Institute for Technology in Psychiatry, McLean Hospital, Harvard University, Belmont, Massachusetts., Ressler KJ; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Depression and Anxiety Disorders, McLean Hospital, Harvard University, Belmont, Massachusetts; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Olson EA; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, Massachusetts., Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Korgaonkar MS; Brain Dynamics Centre, Westmead Institute of Medical Research, Westmead, New South Wales, Australia., Andrew E; Department of Psychology, University of Sydney, Westmead, New South Wales, Australia., Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Ipser J; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Peverill M; Department of Psychology, University of Washington, Seattle, Washington., Sambrook K; Department of Radiology, University of Washington, Seattle, Washington., Gordon E; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Washington University School of Medicine, St. Louis, Missouri., Baugh LA; Division of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Sioux Falls VA Health Care System, Sioux Falls, South Dakota., Forster G; Division of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand., Simons RM; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Department of Psychology, University of South Dakota, Vermillion, South Dakota., Simons JS; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Department of Psychology, University of South Dakota, Vermillion, South Dakota., Magnotta VA; Department of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, Iowa., Maron-Katz A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California., du Plessis S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa., Disner SG; Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota., Davenport ND; Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota., Grupe D; Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin., Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin., deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Fitzgerald J; Department of Psychology, Marquette University, Milwaukee, Wisconsin., Krystal JH; Division of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut., Levy I; Division of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut., Olff M; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; ARQ National Psychotrauma Centre, Diemen, the Netherlands., Veltman DJ; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Wang L; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Neria Y; Department of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York., De Bellis MD; Healthy Childhood Brain Development Developmental Traumatology Research Program, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina., Jovanovic T; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, Michigan., Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, the Netherlands., Shenton ME; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; VA Boston Healthcare System, Brockton Division, Brockton, Massachusetts., van de Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., Schmahl C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Women's Mental Health, McLean Hospital, Harvard University, Belmont, Massachusetts., Rosso IM; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, Massachusetts., Sponheim SR; Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota., Hofmann DB; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Bryant RA; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Fercho KA; Division of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Sioux Falls VA Health Care System, Sioux Falls, South Dakota; Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, Oklahoma., Stein DJ; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium; Department of Personality, Psychological Assessment and Treatment, University of Deusto, Bilbao, Spain., Phan KL; Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois; Mental Health Service Line, Jesse Brown VA Chicago Health Care System, Chicago, Illinois., McLaughlin KA; Department of Psychology, Harvard University, Cambridge, Massachusetts., Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin; Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin; Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin., Larson C; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin., May G; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, Texas., Nelson SM; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, Texas., Abdallah CG; Division of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut., Gomaa H; Department of Psychiatry, Pennsylvania State University, State College, Pennsylvania., Etkin A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California; VA Palo Alto Health Care System, Palo Alto, California., Seedat S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa., Harpaz-Rotem I; Division of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut., Liberzon I; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan., Wang X; Department of Psychiatry, University of Toledo, Toledo, Ohio., Thompson PM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California., Morey RA; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina. Electronic address: rajendra.morey@duke.edu.
Jazyk:	angličtina
Zdroj:	Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2022 Sep; Vol. 7 (9), pp. 935-948. Date of Electronic Publication: 2022 Mar 15.
DOI:	10.1016/j.bpsc.2022.02.008
Abstrakt:	Background: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). Methods: Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks. Results: Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks. Conclusions: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD. (Copyright © 2022 Society of Biological Psychiatry. All rights reserved.)
Databáze:	MEDLINE
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