Multivariable Diagnostic Prediction Model to Detect Hormone Secretion Profile From T2W MRI Radiomics with Artificial Neural Networks in Pituitary Adenomas.
| Autor: | Baysal B; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Radiology, Istanbul, Turkey., Eser MB; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Radiology, Istanbul, Turkey., Dogan MB; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Radiology, Istanbul, Turkey., Kursun MA; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Radiology, Istanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Medeniyet medical journal [Medeni Med J] 2022 Mar 18; Vol. 37 (1), pp. 36-43. |
| DOI: | 10.4274/MMJ.galenos.2022.58538 |
| Abstrakt: | Objective: This study aims to develop neural networks to detect hormone secretion profiles in the pituitary adenomas based on T2 weighted magnetic resonance imaging (MRI) radiomics. Methods: This retrospective model-development study included a cohort of patients with pituitary adenomas (n=130) from January 2015 to January 2020 in one tertiary center. The mean age was 46.49±13.69 years, and 76/130 (58.46%) were women. Three observers segmented lesions on coronal T2 weighted MRI, and an interrater agreement was evaluated using the Dice coefficient. Predictors were determined as radiomics features (n=851). Feature selection was based on intraclass correlation coefficient, coefficient variance, variance inflation factor, and LASSO regression analysis. Outcomes were identified as 7 hormone secretion profiles [non-functioning pituitary adenoma, growth hormone-secreting adenomas, prolactinomas, adrenocorticotropic hormone-secreting adenomas, pluri-hormonal secreting adenomas (PHA), follicle-stimulating hormone and luteinizing hormone-secreting adenomas, and thyroid-stimulating hormone adenomas]. A multivariable diagnostic prediction model was developed with artificial neural networks (ANN) for 7 outcomes. ANN performance was presented as an area under the receiver operating characteristic curve (AUC) and accepted as successful if the AUC was >0.85 and p-value was <0.01. Results: The performance of the ANN distinguishing prolactinomas from other adenomas was validated (AUC=0.95, p<0.001, sensitivity: 91%, and specificity: 98%). The model distinguishing PHA had the lowest AUC (AUC=0.74 and p<0.001). The AUC values for the other five ANN were >0.85 and p values were <0.001. Conclusions: This study was successful in training neural networks that could differentiate the hormone secretion profile of pituitary adenomas. Competing Interests: Conflict of Interest: The authors have no conflict of interest to declare. (© Copyright Istanbul Medeniyet University Faculty of Medicine.) |
| Databáze: | MEDLINE |
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