Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina.

Autor: Fauzi A; Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Suhendro; Tropical medicine Division Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Simadibrata M; Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Rani AA; Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Sajuthi D; Primate Research Centre, Institut Pertanian Bogor, Bogor, Indonesia., Permanawati; Primate Research Centre, Institut Pertanian Bogor, Bogor, Indonesia., Amanda R; Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Makmun D; Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Jazyk: angličtina
Zdroj: Journal of medical primatology [J Med Primatol] 2022 Jun; Vol. 51 (3), pp. 134-142. Date of Electronic Publication: 2022 Mar 20.
DOI: 10.1111/jmp.12577
Abstrakt: Background: Acute pancreatitis exhibits a rapid clinical progression which makes it difficult to observe in human; hence, an experimental animal model is needed. This preliminary study performed an induction of acute pancreatitis using glycodeoxycholic acid (GDOC) in an experimental macaque model.
Methods: GDOC injections (initial dose of 11.20 mg/kg) were administered in an escalating manner at specific time points. The injection was given along the bilio-pancreatic duct, followed by measurement of vital signs, serum amylase-lipase, TNF-α, procalcitonin, oxidative stress parameters, and microscopic and macroscopic findings.
Results: The results indicated that acute pancreatitis occurred following induction with low-dose GDOC. Serum amylase and lipase levels increased with subsequent GDOC injections. Blood pressure and heart rate were elevated, indicating abdominal pain. Changes in TNF-α, procalcitonin, and oxidative stress values showed active inflammation. We observed histologic features of pancreatitis and as the dose increased, vasodilation of the splanchnic vasculatures was observed.
Conclusions: Small dose GDOC injection in the bilio-pancreatic duct may have a role to induce acute pancreatitis in Macaca nemestrina.
(© 2022 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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